Carbohydrate moiety of von willebrand
factor is not necessary for maintaining multimeric structure and ristocetin cofactor activity but protects from proteolytic degradation.
Helicobacter pylori binds von Willebrand
factor and interacts with GPIb to induce platelet aggregation.
Among multiple prediction models examined, a model consisting of inhalation injury, the von Willebrand
factor biomarker and the per cent of body burned did the best job of predicting which patients were most likely to develop ARDS.
Lower levels of von Willebrand
factor may be linked to higher levels of haemorrhage.
The World Federation of Hemophilia (WFH), a US-based humanitarian organization, has pegged the number of Filipinos with hemophilia at 10,000 and those with von Willebrand
Disease at one million.
In vascular injury, von Willebrand
factor (vWF) together with platelets initiates the formation of thrombus.
And up to half of those with menorrhagia at menarche may have von Willebrand
, as do one in six adolescents who go to the emergency department because of heavy menstrual bleeding.
Studies have reported that half of the epistaxis patients had blood group O and blood group O was associated with a lower expression of vWF (Von Willebrand
factor) [10, 11] as compared with non-O groups.
In a statement, Villanueva said the country's health care system remains ill-equipped in handling bleeding disorders, including hemophilia and the Von Willebrand
Specifically, we focus on platelet activation, von Willebrand
factor (VWF) conformational changes, and VWF-platelet interaction.
The story of von Willebrand
factor starts in Finland in the first years of the 1900s.
disease (VWD) is the most commonly inherited bleeding disorder with a prevalence of at least 0.1% and a global population of approximately 5.8 million affected individuals .
Types of bleeding disorders that may present with epistaxis include coagulation factor deficiencies, Von Willebrand
disease, and several rare inherited platelet function disorders associated with defects in specific aspects of platelet function (Table 1).
Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF: ristocetin cofactor assay, and negative Bethesda assay, indicating acquired von Willebrand
Recognition of acquired von Willebrand
syndrome (AVWS) and its many causes, including malignancy, is important and a high level of suspicion for AVWS must be maintained in the workup of bleeding disorders.