Naturally occurring alkaloids such as morphine and the anti-cancer drug vinblastine
are already extracted from plants for medical applications.
* PVB regimen: cisplatin, vinblastine
, and bleomycin
patients with melanoma, head and neck, nonsmall cell lung, ovarian, cervix, breast, colon or rectal cancers demonstrated the ability of amifostine to reduce the normal tissue toxicities, but not antitumor activities associated with cisplatin, vinblastine
, carboplatin, myotoxin and radiation.
Combinations being evaluated include strontium plus estramustine and vinblastine
, strontium plus doxorubicin, and strontium plus mitoxantrone and hydrocortisone (Vogelzang et al., 1998).
The approval is based on the results of the randomized, open-label, two-arm, multi-center Phase 3 ECHELON-1 study designed to compare Adcetris plus AVD to ABVD (Adriamycin, bleomycin, vinblastine
and dacarbazine) as a therapy in adult patients with previously untreated Hodgkin lymphoma.
Seattle Genetics (SGEN) announced that its collaborator, Takeda (TKPYY), has received approval from the Japanese Ministry of Health, Labour and Welfare for ADCETRIS in combination with doxorubicin, vinblastine
and dacarbazine as a frontline treatment option for CD30-positive Hodgkin lymphoma patients in Japan.
Various anti-cancer drugs such as epidermal growth factor receptor (EGFR) inhibitors including cetuximab and gefitinib, multikinase inhibitors (Imatinib, sorafenib), taxanes (Paclitaxel), vinca alkaloids (Vincristine, vinblastine
), antimetabolites (6-mercaptopurine, 5-fluorouracil, Cytarabine, capecitabine, gemcitabine), genotoxic agents (Cisplatin, carboplatin, oxaliplatin, etoposide, cyclophosphamide, and anthracyclines like doxorubicin, daunorubicin, epirubicin), hydroxyurea, cyclophosphamide, doxorubicin, vincristine, prednisolone (CHOP) and ABVD (Doxorubicin, bleomycin, vinblastine
, dacarbazine) regimens are associated with prominent and sometimes dose-limiting dermatologic complications.
For second-line chemotherapy and salvage chemotherapy, we administered vinblastine
, ifosfamide, and cisplatin (VelP), with intravenous ifosfamide (1200 mg/[m.sup.2]) and intravenous cisplatin (20 mg/[m.sup.2]) administered on days 1-5 and vinblastine
(0.11 mg/kg) administered on days 1 and 2.
This case highlights an aggressive form of LCH that responded to vinblastine
after failing cytarabine and nivolumab.
(VIN) and paclitaxel (PTX) have been widely used as anticancer agents because they interfere with microtubules by either inhibiting microtubule assembly (VIN) or disassembly (PTX).
A 6-month course of chemotherapy with vinblastine
and prednisolone was administered.
Other treatments include local destruction (cryotherapy), topical alitretinoin (9-cis-retinoic acid), intralesional interferon or vinblastine
, superficial radiotherapy, liposomal doxorubicin, daunorubicin, or paclitaxel.
and prednisone were given for the treatment of LCH, which were effective for about three years.
This is because bladder cancer patients with a lower GFR (50-59 mL/min/1.73m[sup.2]) showed poorer survival rates compared to those with GFR above 60 mL/min/1.73m[sup.2] when treated with NAC (cisplatin, methotrexate and vinblastine
).[sup.18] Similar to previous reports,[sup.15,19] in the 46% of patients in this series who were ineligible for NAC, the primary reason was inadequate renal function.
For example, several anti-cancer drugs including, vinblastine
and paclitaxel are exclusively derived from botanicals.