According to the company, JX-970 is an oncolytic virus that is derived from a Western Reserve strain vaccinia
virus and its tumor selectivity has been optimized through deletion of thymidine kinase (TK) and vaccinia
growth factor (VGF).
Our data show that the eye was co-infected with 2 VACV and demonstrates the detection and isolation of VACV from a natural case of ocular vaccinia
Adverse reactions to vaccinia
vaccination range from mild and self-limited to severe and life-threatening, including inoculation site signs and symptoms, constitutional symptoms, generalized vaccinia
, eczema vaccinatum, and progressive vaccinia
Poxviruses like vaccinia
virus, owing to their large genome size, can accommodate a large part of deletion in their genome without compromising their ability to replicate in the cells and can, therefore, insert a number of genes of foreign origin (~25 kb), leading to the production of multivalent vaccines (4,5).
In the last years, many cases of human disease associated with bovine vaccinia
were reported in some Brazilian states, such as Sao Paulo, Minas Gerais, Rio de Janeiro, and Goias (TRINDADE et al.
virus is best known as the basis of the vaccine that eradicated smallpox.
The team studied how vaccinia
virus, when altered to delete the E3L gene, evolved to successfully replicate in the presence of human PKR.
Scientists have known for many years that the well-studied vaccinia
poxvirus uses two proteins to inhibit the protein kinase R response.
While these results are very interesting and hopefully may lead to a new weapon against the HIV pandemic, they are preliminary and it is far too soon to recommend the general use of vaccinia
immunisation for fighting HIV," the team said.
Smallpox was eradicated worldwide in 1980, after a large vaccination campaign, in which Vaccinia
virus was used as a vaccinal vector, due to its high genetic similarity with the smallpox virus.
He eventually recovered, but subsequent test results showed he had suffered from vaccinia
virus infection that did not match the type of virus strain used in experiments in the laboratory where he worked.
Scientists in Hong Kong and the United States have developed an experimental H5N1 bird flu vaccine for people by piggybacking it on the well-tested vaccinia
vaccine that was used successfully to eradicate smallpox.
vaccines insert specific genes into the vaccinia
virus, which makes the virus more immunogenic.
Researchers overcame that by using genetically engineered vaccinia
, a relative of the smallpox virus, which spreads more easily in cancer tumors.
is related to, but different from, the virus that causes smallpox, and works by causing a mild infection that stimulates an immune response that will protect against smallpox, according to the FDA.