His major work, An Inquiry Into the Nature and Treatment of Gravel, Calculus, and Other Diseases Connected with a Deranged Operation of the
Urinary Organs (1821), was very popular and helped establish his reputation in Great Britain and Europe as one of Britain's distinguished physiological chemists.
The cancer sites that showed positive trends of increasing cancer mortality with increasing wheat acreage were esophagus, stomach, rectum, pancreas, larynx, prostate, kidney and ureter, brain, thyroid, bone, and all cancers (men) and oral cavity and tongue, esophagus, stomach, liver and gall bladder and bile ducts, pancreas, cervix, ovary, bladder, and other
urinary organs, and all cancers (women).