nephropathy

(redirected from urate nephropathy)
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Synonyms for nephropathy

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The pathogenesis of chronic urate nephropathy involves the persistent deposition of sodium urate crystals in the interstitial tissue of the renal medulla; these crystals might activate the local renin-angiotensin-aldosterone system; damage endothelial cells; and cause high glomerular pressure, chronic inflammatory reactions, interstitial fibrosis, and other pathological changes.[77] If HUA patients develop renal tubular dysfunction, such as increased nocturia, low specific gravity urine, and low-molecular-weight proteinuria, chronic urate nephropathy is suspected.
Acute urate nephropathy was seen in four cases out of which three cases had acute leukemia and one had multiple myeloma.
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc.
Urate crystal deposition in the kidney is the most common and can present as acute uric acid nephropathy, chronic urate nephropathy, or uric acid nephrolithiasis.
About half of cases involve the big toe, but it can present as gouty tophi (a deposit of monosodium urate crystals in the joints, cartilage, bone, and throughout the body that may break out through the skin), kidney stones, or urate nephropathy.