After stabilization (20min), tubocurarine
or individual alkaloids were added cumulatively in order to establish concentration-inhibition curves.
Table One: Sample list of neuromuscular blocking agents available in Canada Generic Name Common Trade Name atracurium Tracrium cisatracurium Nimbex mivacurium Mivacron pancuronium Pavulon succinylcholine ([dagger]) Quelicin ([dagger]) tubocurarine
Tubarine vecuronium Norcuron ([dagger]) Depolarizing neuromuscular blocking agent.
Blood products, iodine contrast, opioids and even tubocurarine
are commonly associated with anaphylactoid reactions.
However, charged molecules such as tubocurarine
can also enter the fetus (Kivalo and Saarikoski 1972, 1976).
The fish were injected with tubocurarine
Familiar examples of plant-derived drugs include the potent analgesics morphine and codeine, from the poppy (Papaver somniferum); the antimalarial drug quinine, from Cinchona pubescens; the powerful muscle relax ant tubocurarine
, from Chondrodendron tomentosum; digitoxin, a cardiotonic from the foxglove plant (Digitalis purpurea); and ephedra, a component of many over-the-counter antihistamines, from Ephedra sinica.
A comparison of tubocurarine
, Rocuronium and cisatracuronium in the prevention and reduction of succinylcholine induced muscle fasciculations.
Observations of indigenous medicinal practices have always proved useful in the discovery of many modern drugs like quinine, artemisinin, aspirin, atrophine, digoxin, ephedrine, morphine, reserpine, tubocurarine
, vinblastine, vincristine, and taxol, to name only a few (Gilani and Rahman 2005).
A number of modern drugs like aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine
are examples, which were originally discovered through observations of traditional cure methods of indigenous peoples [Gilani and Rahman, 2005].
In 1950, after a decade of 11 other unpublished New Zealand cases of tetanus with two recoveries, and another series treated by basal sedation with 50% surviving, DW Beaven (50) and his Christchurch team supplied a six-year-old boy with anaesthetic doses of tribromoethanol with 350 mg tubocurarine
(d-TC) over [greater than or equal to] 12 days, to control his tetanus spasms and severe opisthotonus.