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Related to tolbutamide: acarbose, metformin
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Synonyms for tolbutamide

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Group Substance Category I 400 mg/kg of Tinospora juice (4 mL) Test II 250 mg/kg of Tolbutamide dissolved Standard in 4 mL distilled water III 4 mL distilled water Control After 1 hour, each animal was given 3 gm/kg bodyweight of glucose dissolved in 1 mL of distilled water.
Persistent hypoglycemia is induced by tolbutamide administration in broiler chickens fed a low-carbohydrate diet.
Phenacetin (purity > 99%), omeprazole (purity > 98%), tolbutamide (purity > 98%), and metoprolol (purity > 99%) were purchased from Toronto Research Chemicals Inc.
The first was tolbutamide under the trade name Orinase from Upjohn Co.
Six drugs are included in this subclass: chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide. These agents were among the first oral antidiabetic agents.
This approach has been used to study the allosteric interactions between warfarin and tamoxifen on HSA (34), the effect of tolbutamide on the binding of S-warfarin with HSA (27), and the allosteric effects that occur as S-propranolol and warfarin bind to AGP (17).
Zhang et al., "Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats," Biomedical Chromatography, vol.
CM082, its metabolites, and tolbutamide were dissolved in DMSO to generate 1.0 mg/ml stock solutions stored at 4[degrees]C.
Lenzen, "The immediate insulin secretory response of the rat pancreas to glucose compared with tolbutamide and other secretagogues," Diabetes, vol.
Tolbutamide (Product number 1002039664) and chlorzoxazone (Product number 1001433956) were purchased from Sigma-Aldrich Co., Ltd.
Phenacetin (>98.0%), tolbutamide (>99.0%), chlorzoxazone (>99.0%), testosterone (>98.0%), and the internal standard tinidazole (IS) (>99.0%) were purchased from Dalian Mellon Biological Technology (Dalian, China).
Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin-dependent diabetes mellitus The American Journal of Medicine, 98(5), 443-451.
Berberine also displaces warfarin, thiopental and tolbutamide from their protein binding sites, increasing their plasma levels (Tan et al.
studied new insight into the role of BAD in glucose-stimulated insulin secretion by [beta]-cells from [Bad.sup.-/-] compared with [Bad.sup.+/+] islets (Figure 8) [88]: Perifused islets from [Bad.sup.-/-] mice secreted significantly less insulin in response to 25 mM glucose compared to that of [Bad.sup.+/+] mouse islets at about 40% for the first phase secretion (minutes 0-15) and at 60% for the second phase secretion (minutes 15-40) than those of [Bad.sup.+/+] islets (Figure 8A and B) [88], however, the total insulin secretion by 30 mM KCl (Figure 8A) [88], glucose-induced (25 mM) changes of ATP/ADP ratio (Figure 8C) [85,88] and insulin secretion in response to 10 mM KIC and 25 mM tolbutamide were compatible in both [Bad.sup.+/+] and [Bad.sup.-/-] islets (Figure 8D) [88].
Hypoglycemic and hypotriglyceridemic effects of tolbutamide in triphenyltin chloride-induced diabetic rabbits.