Normally, the gut has a healthy barrier, which includes a mucus layer and a layer of cells that are connected by tight junctions
, acting like doorways that allow nutrients from food to be transported out of the gut and into the blood stream.
Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction
protein expression via modulation of the Ras signaling.
2013) Claudins and the modulation of tight junction
For example, acetaldehyde destabilizes tight junctions
by redistributing proteins (Dunagan et al.
In addition, Li and Neu's experiment showed that Gln could regulate intercellular junction integrity and tight junction
proteins through the PI3K/Akt signaling pathway.
Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions
ATPase regulates tight junction
formation and function during mouse preimplantation development.
Toborek, "PPARa and PPARy attenuate HIV-induced dysregulation of tight junction
proteins by modulations of matrix metalloproteinase and proteasome activities," The FASEB Journal, vol.
marker, claudin, also showed a significant increase (P=0.
The tight junction
strands are predominantly formed by claudins, a family of four-transmembrane proteins (Fig.
Evaluation of tight junction
protein 1 encoding zona occludens 1 as a candidate gene for albuminuria in a Mexican American population.
Highlights include: * The nano-injection molding process results in an industry-leading seamless tight junction
connecting a 1.
Hochman, 2012), and recent studies have reported that zonulin may affect the tight junction
permeability of the blood-brain barrier (1.
In the study, histologic analyses also showed that improved spongiosis scores in treated patients correlated with increased density of two tight junction
proteins, filaggrin (P = .
This finding also suggested that the intestinal absorption of phenylethanoid glycosides was restricted when the epithelial tight junction
was tight enough.