thrombin


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Related to thrombin: antithrombin, Thrombin time
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  • noun

Words related to thrombin

an enzyme that acts on fibrinogen in blood causing it to clot

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Thrombin is a proven blood coagulation agent used on its own or in combination with other hemostats that has been estimated to be used in more than one million patients per year in the United States to help surgeons address intraoperative bleeding.
Thrombin is a proven blood coagulation agent--used on its own or in combination with other hemostats--estimated to be used in over 1 million patients per year in the United States to help surgeons address intraoperative bleeding.
When applied to the skin tissue the microneedles pierce the cutaneous layers and are able to detect alterations in the level of thrombin enzymes.
Historically, thrombin generation has been investigated by means of the basic tests of coagulation, prothrombin time (PT) and activated partial thromboplastin time (APTT).
Thrombin is a pleiotropic enzyme, performing various actions to activate protease-activated receptors expressed on the endothelial cells, leukocytes, vascular smooth-muscle cells, fibroblasts, and platelets.
Thrombin (Thrombin-JMI, Evithrom, Recothrom) is derived from bovine, human, or recombinant sources.
Its measurement on admission is not recommended because the antithrombin level may be reduced because of the generation of the thrombin that caused the thrombotic event.
The system consists of iron oxide nanoparticles, which the Food and Drug Administration has approved for human use, coated with peptides (short proteins) that are specialized to interact with thrombin.
In the last decade, percutaneous thrombin injection has become the treatment of choice for iatrogenic femoral artery pseudoaneurysm.
Since DTIs act independently of antithrombin, they can inhibit thrombin bound to fibrin or fibrin degradation products.
Some ophthalmological surgeries, such as, flap extraction, that is, removal of a cataract by making a flap in the cornea, antiglaucomatous sclerectomy and dacryocystorhinostomy are fraught with profuse hemorrhage exhibiting dependencies on changes in hemostasis parameters, including prothrombin time, thrombin clotting time and number of platelets.
3) Given its central role in the clot formation, thrombin is an attractive target for the development of agents that effectively interfere with thrombogenesis.
ProFibrix BV, a developer of products for hemostasis and regenerative medicine, said on Thursday that the company has signed an agreement for the clinical and commercial supply of plasma-based fibrinogen and thrombin for the manufacture of Fibrocaps.
A qualified majority of members of the European Parliament rejected, on 19 May, the use of thrombin with fibrinogen as a food additive as proposed in a draft European Commission directive.