1997, 1998) with BSE in the dose range of 300-350 mg at 8 hourly frequency have been reported effective, we believe that 333 mg of BSE, three times a day will give adequate therapeutic plasma concentration
Similar signs of toxicity have also been reported in humans, in whom voriconazole therapeutic plasma concentration
for Aspergillus spp infections is 2-6 [micro]g/mL.
The long-acting formulation is usually administered once and is expected to maintain a therapeutic plasma concentration
for 3 to 4 days, whereas the short-acting formulation is recommended for daily use for 3 to 4 days to maintain a therapeutic plasma concentration
The main goal of this research programme is to couple Brefeldin A (BFA) with Aphios' SuperFluids critical fluid nanosomes (SFS-CFN) technology for intravenous administration to achieve and maintain therapeutic plasma concentrations
. The nanoBFA IV research is being funded via a research subcontract from Leidos Biomedical Research Inc, prime contractor for the Frederick National Lab, sponsored by the National Cancer Institute.
It has previously been demonstrated that postoperative intravenous paracetamol provides faster onset of analgesia than a similar dose given orally (2) and, more recently, that only two-thirds of patients given an oral dose of 1.0 g paracetamol preoperatively achieved therapeutic plasma concentrations
at any point compared to 96% in those given 1.0 g intravenously preoperatively (3).