The company has created more than 3,000 novel tetracycline compounds using its proprietary technology platform.
Tetraphase Pharmaceuticals, Inc., is a biopharmaceutical company using its proprietary chemistry technology to create novel tetracyclines for serious and life-threatening conditions, including infections caused by many of the multidrug-resistant bacteria highlighted as urgent public health threats by the World Health Organization and the Centers for Disease Control and Prevention.
The highest level of resistance was to ampicillin (56.1%), followed by nitrofurantoin (43.9%), tetracycline (41.4%), cefotaxime (37.8%), nalidixic acid (29.3%), ciprofloxacin (23.1%), co-trimoxazole (21.9%), meropenem (14.6%), imipenem (12.2), chloramphenicol (7.3%), gentamicin (4.9%), piperacillin-tazobactum (3.7%).
Of 34 isolates resistant to tetracycline, seven isolates harbored more than one resistance gene (1-tetA & tetD, 1-tetA, tetC & tetS, 2-tetC & tetE, 2-tetC & tetS and 1-tetC, tetD & tetE), 4 carried tetA gene and 1 carried tetB gene.
The long-held view that tetracycline
medicaments cause staining is based on the outcomes of the systemic administration of tetracycline
antibiotics to young patients during periods of tooth formation, when they become incorporated into the tooth structure and from previous in vitro studies.
Susceptibility to erythromycin and tetracycline
was determined by the disc diffusion method, as described earlier .
Littermate mice were distributed into four groups: the control group, which was only infected but received no further treatment; the antibiotic-treated group, which was treated topically with 20 [micro]L of antibiotics (tetracycline
2.5 [micro]g/mL when A.
Resistance was second highest for ciprofloxacin in the central region with 20% resistant to ciprofloxacin alone (5%), in combination with tetracycline
(10%), or with other two drugs (5%).
(TC) and its derivatives are among the most commonly used antimicrobials worldwide.
The inhibition zone diameters obtained for penicillin G ([less than or equal to] 19mm), vancomycin ([less than or equal to] 14mm), tetracycline
([less than or equal to] 14mm), chloramphenicol ([less than or equal to] 13mm) and erythromycin ([less than or equal to] 13mm) were determined according to the breakpoints proposed for Lactobacillus sp.
Antimicrobial drug resistance in GAS in South Korea is closely associated with emm28, and resistance to tetracycline
(observed emerging in 2015) is associated with type emm1.
coli revealed cent percent sensitivity to Chloramphenicol, Amoxicillin, Norfloxacin, Enrofloxacin, Gentamicin and Tetracycline
, while 95.65% isolates were sensitive to Amikacin and 86.96% to Ciprofloxacin.
 developed a multiresidue assay for banned in-feed drugs, including sulfonamides, fluoroquinolones, and tetracycline
, in swine tissue using matrix solid phase dispersion (MSPD) as a sample pretreatment method.
Isoflavone reductase was present only in seedlings growing with tetracycline
uptake from soil modify mainly the changes in biochemical processes connected with protein.
Objective: To compare the efficacy of oral azithromycin with topical tetracycline
for treating chronic trachoma in rural Sindh population of Pakistan.