The lesion described in our case 1 comes under group 8 of Frieden classification which occurs after teratogen
are compounds that are known to cause malformation in embryos.
Furthermore, the bioactive teratogenic compounds present can also be develop into an anticancer drugs since almost anticancer drugs are teratogens
A possible contributing factor is that first pregnancies may be more likely to be unplanned and may be associated with more risk of maternal teratogen
exposure and the effects of inadequate diet and nutritional deficiencies.
2) The embryonic period (from 3-9 weeks) is the most sensitive period during which teratogens
can be particular damaging.
is an agent that promotes physical defects in a developing embryo.
This includes whole embryo culture tests, organ culture teratogen
Nearly 15 years ago, in this same journal, we described congenital LCMV as an unrecognized teratogen
and recommended further "research to define the frequency of LCMV" (2).
For over 30 years research has shown that alcohol is a teratogen
that is capable of effecting the growth and development of the fetus from pre-embryonic and embryonic development through to and including fetal growth.
Although many authors have suggested that carbamazepine is not a teratogen
and it is the first choice for women who require an anticonvulsant during pregnancy, some studies have shown that carbamazepine is associated with major malformations (3, 4).
Meclizine, an antihistamine used to treat nausea and vomiting, was proven a potent teratogen
for rats, causing abnormalities such as cleft palate, small mouth, short limbs, receded lower jaw, and unclacified vertebral bodies in rat offspring (King, 1963).
Researchers also note that since it is a relatively weak teratogen
compared to other pesticides, it is used more often in the home, without specific consideration of whether pregnant women or young children are present.
If studies of larger populations confirmed their findings that ethanol (rather than other substances in alcoholic beverages) was a teratogen
, by what means did it act?
Kenneth Lyons Jones of the University of California, San Diego and his colleagues studied 228 pregnant women who called the California Teratogen
Information Service (CTIS) from 1989 through 1995 because they were taking fluoxetine.
REPRORISK now includes TERIS Teratogen
Information System, Shepard's Catalog of Teratogen
Agents, The REPROTOX database and REPROTEXT Reproductive Hazard Reference.