Stemline Therapeutics (NASDAQ:STML), a clinical stage biopharmaceutical company, has revealed the clinical trial results of SL-701, a synthetic peptide vaccine
, it was reported yesterday.
This molecule, localized in the tegument, protonephridia and the female reproductive system (13), is one of the schistosome vaccine candidates (14) under evaluation in our laboratory as part of a multi-component synthetic peptide vaccine
. Being aware that one of the strategies for survival of parasites under different conditions is the re dundancy of key molecules that could allow them to evade the host immune response (15, 16), we combined a proteomic and an immunological approach to confirm if a potential protective epitope synthesized chemically is present in different Sm28GST isoforms of isolated parasites from different geographic origin.
Immunologic and therapeutic evaluation of a synthetic peptide vaccine
for the treatment of patients with metastatic melanoma.
- US-based biotechnology company United Neuroscience has posted positive Phase 1 data for UB-311, its novel synthetic peptide vaccine
targeting beta amyloid in the treatment of AD, the company said.
The synthetic peptide vaccines
are usually composed of 20-30 amino acids targeting the specific epitopes of tumor antigens.