The occurrence and development of malignant tumors are mainly caused by the activation of oncogene and inactivation of tumor suppressor genes
. In colorectal cancer (CRC), tumor suppressor genes
are significantly inhibited with the progression of cancer.
These are proto-oncogenes (promote growth), tumour suppressor genes
(inhibit growth), apoptotic genes (regulate programmed cell death) and DNA repair genes.
Tumor suppressor genes
or anti-oncogenes are lost due to chromosomal alterations during tumor formation.
However, once it is a broad and complex subject, in this work the tumor suppressor genes
will be particularly emphasized, with particular highlight to the p53 gene and protein.
In the women whose biopsy results did not indicate cancer, methylation of another tumor suppressor gene
, called SFRP1, was more common in milk from the biopsied breast than the other breast.
The scientists studied the effects of certain naturally-occurring ITCs on a variety of cancer cells, including lung, breast and colon cancer, with and without the defective tumor suppressor gene
A team of University of Kentucky researchers found a tumor suppressor gene
called Par-4 in the prostate and discovered that the gene kills cancer cells but not normal cells.
The gene DCC (Deleted in Colorectal Cancer) is a putative tumor suppressor gene
within the 18q21.2 region, but the importance of D CC bias been questioned.
On the basis of analysis of 13 SNPs within the genomic region of the potential tumor suppressor gene
PPP2R3B, located in the terminal band Xp22.3 (6, 7), we established a matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOFMS) approach to analyze LOH in nonmicrodissected tissue.
Dr Serrano's group previously produced similar results with a mouse given an extra copy of the tumour suppressor gene
Dr Hani Gabra, who led the research at the charity's Edinburgh oncology unit, said, ``This is a very important discovery in identifying what seems to be the key tumour suppressor gene
in ovarian cancer.''
The patients had severe polyposis phenotypes with a mutation in exon 15G of the tumor suppressor gene
adenomatous polyposis coil.
Loss of heterozygosity at the p53, Rb, DCC and APC tumor suppressor gene
loci in human bladder cancer.
Levine codiscovered an important tumor suppressor gene
called the p53 protein.
In a study published in the July issue of the American Journal of Obstetrics and Gynecology(2000;183:39-45), the investigators found that the test could be used to identify human papillomavirus E6 and the tumor suppressor gene
p53, both of which are linked to the development of cervical cancer.