The Chief Executive Officer of SGC is Aled Edwards, a world-leading expert in proteomics and structural genomics
research, and a professor at the University of Toronto.
2] Nonstandard abbreviations: FDA, Food and Drug Administration; PPP, private-public partnership; SGC, Structural Genomics
Consortium; IVD, in vitro diagnostics.
It was reported yesterday that the organisation has signed an open-access global research partnership with the Structural Genomics
Consortium to discover and characterise novel drug targets for myeloma.
The National Institute of General Medical Sciences, part of the National Institutes of Health, has announced plans for a new direction of the Protein Structure Initiative, a structural genomics
effort started in 2000.
Papers address structural genomics
and in silico analysis in chapters discussing the physical structure of the plant nuclear genoe, plant nuclear genome sequencing, bioinformatics, databases in biology, gene prediction, detecting protein function from genome sequences, and large-scale sequence comparisons.
First demonstrated in the mid-1940s, this physics-heavy technique has moved to the forefront within life sciences, particularly in medicine, and in more recent years, in the structural genomics
arena for the purpose of protein structure determination.
Using structural genomics
, we can compare DNA sequences among individuals of a species to reveal minor variations in the DNA nucleotide code at certain positions in the genome, called "single-nucleotide polymorphisms," or SNPs (pronounced "snips").
It supplements structural genomics
, which searches for the chemical makeup of DNA, and functional genomics, which looks for the effects of a gene on an organism.
Andrej Sali, a professor at the University of California, San Francisco, departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, says that scientists working on structural genomics
have become keenly interested in how protein assemblies function.
is the assignment of three-dimensional structures to proteomes and the investigation of their biological implications.
Canada: A handful of pharmaceutical companies and Canadian government and funding organizations have joined with the University of Toronto and the University of Oxford to form the Structural Genomics
Consortium (SGC), a partnership dedicated to mapping and compiling a database of over 350 protein structures.
Recently, the structural biology efforts have centered on enzymes in the chorismate metabolic pathways involved in amino acid biosynthesis and in structural genomics
that involves determining the structures of "hypotheti cal" proteins to aid in assigning function.
The International Structural Genomics
Meeting that ended Friday in the U.
De Novo's proprietary algorithms can convert information from structural genomics
and medicinal chemistry rapidly into new chemical designs, maximizing value within a pharmaceutical partner's research portfolio.
This method, which combines the disciplines of cell biology, structural genomics
, computational chemistry and medicinal chemistry, may accelerate the design and development