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Over 90% of cases are high-grade intramedullary osteosarcoma or spindle cell sarcoma (fibrosarcoma and malignant fibrous histiocytoma) [5].
This patient's histological samples demonstrated a low to intermediate grade spindle cell sarcoma with three to four mitotic figures per 10 high powered fields.
6-cm tibial lesion diagnosed as spindle cell sarcoma by FNACBP with a subsequent diagnosis of MPNST on resection, (2) a 1.
Maureen Howe TOP TREND: Tributes have poured in for Newcastle Uni graduate Hatti Sandall who passed away after losing her battle against the rare form of cancer, Spindle Cell Sarcoma.
3 Rarest of rare is spindle cell sarcoma of vagina having a very poor prognosis.
We present a case in which a hip spacer is used to perform the reconstruction following an extra-articular scapula resection for high grade spindle cell sarcoma.
2,23,24) The dedifferentiated area can be conventional high-grade osteosarcoma with various subtypes (osteoblastic, fibroblastic, chondroblastic, giant cell rich, and telangiectatic) or pleomorphic spindle cell sarcoma.
Inclusion criteria included (1) extremity spindle cell sarcoma (excluding small round cell tumors such as Ewing sarcoma, malignant peripheral nerve sheath tumor, osteosarcoma/ chondrosarcoma, or liposarcoma); (2) absence of metastases at the time of presentation; (3) diagnosis made by either CNB or IB; and, (4) at least 2 years of follow-up (patients who died of causes other than sarcoma were censored at their last follow-up).
3,14) A minority of sarcomas had SYT FISH performed on them, which was negative, but did not have sufficient light microscopic or immunohistochemical features allowing for diagnosis of MPNST; these sarcomas were in the end classified as spindle cell sarcoma, not otherwise specified.
Some malignant cases demonstrate a histologically typical, benign-appearing, solitary fibrous tumor component with an abrupt transition to a high-grade spindle cell sarcoma ("dedifferentiation").
16) These findings in combination with our results again emphasize the limitation of immunohistochemistry and the importance of a broad immunohistochemical panel in the diagnostic workup of a spindle cell sarcoma.