Atypical fibroxanthoma with adjacent solar elastosis
(A) and ulceration (B).
results in the destruction of the coherent mechanically strong and protective fibrous network of dermal collagen, and the substitution of an amorphous gel-like elastotic material.
The two retrospective studies considered me presence of dermal solar elastosis
a surrogate marker for sun damage to skin, and found solar elastosis
in 61% of 368 consecutive cases of cutaneous invasive melanoma, and in 77% of 380 consecutive cases of melanoma in situ diagnosed at the University of Texas Southwestern Medical Center at Dallas.
Acute IR irradiation also increases new, leaky vessel formation and induces inflammatory cellular infiltration and (b) Heat energy, which increases skin temperature, also increases MMP-1, -3, and -12, and modulates elastin and Fibrillin synthesis, resulting in the development of solar elastosis
As such, histologic features related to chronic sun damage such as epidermal atrophy, increased pigmentation in basal keratinocytes, and prominent solar elastosis
are present (Figure 1, A and B).
Regular use of sunscreens for long periods has been shown to reduce the incidence of both solar keratoses  and solar elastosis
As for the mechanism of solar elastosis
, increased elastin mRNA levels resulting from transcriptional up-regulation of the gene have been reported.
Differential diagnosis may include melanoma, compound nevi, angiokeratoma, solar elastosis
, or even open comedones.
They also found similar increases in survival likelihood related to overall sun exposure and to the presence of marked solar elastosis
In sharp contrast to lentigo maligna, there is only limited or no solar elastosis