Can calcium and sodium channel blockers
attenuate hemodynamic responses to endotracheal intubation?
In individuals in whom the ECG is normal, the characteristic findings can be elicited by the administration of procainamide, flecanide, or ajmaline, a sodium channel blocker
47), and in patients with a spontaneous form compared with sodium channel blocker
induced type I ECG (RR 4.
1-3) These ECG changes are dynamic, often hidden, and may reveal themselves in the presence of triggers like fever, intoxication (alcohol, cocaine, or cannabis), vagal stimulation, electrolyte imbalance, anesthetics (propofol, bupivacaine), psychotropic agents (amitriptyline, lithium), or sodium channel blockers
Highlights will include insight into the controlling of the excitability of peripheral nerves; potential propagation in different subtypes of sensory neurons; the firing pattern of exons; and sodium channel blockers
Recently, we have introduced a way to target the delivery of sodium channel blockers
selectively to nociceptive neurons, and thus capitalize on their effectiveness in blocking action potentials but now only at sites of pain generation.
In suspected patients, induction especially by sodium channel blockers
is helpful in the diagnosis.
Sodium channel blockers
and "pure" potassium channel blockers actually increase mortality, calcium channel blockers have no effect, and, although amiodarone reduces arrhythmic death, it had no effect on total mortality in the 2 largest trials.
For lancinating pain, which is best relieved by sodium channel blockers
, oxcarbazepine or lamotrigine is a first choice, carbamazepine a second choice.
In addition, no definitive evidence that these approaches (ie, sodium channel blockers
, exogenous potassium, or potassium channel openers) improve survival has been published.
A dramatic example was the rise in mortality among heart-attack survivors resulting from the use of sodium channel blockers
to treat asymptomatic arrhythmias.