Caption: Figure 6: Quantification of inflammatory infiltrates and fibrosis area in the skeletal muscle
. Representative images of skeletal muscle
sections stained by conventional H&E stain for analysis of inflammatory infiltrates in naive (a) or infected mice submitted to treatment with saline (b), MSCs (c), or MSC_IGF-1 (d).
metastases are uncommon and usually discovered at autopsy with studies suggesting an incidence as low as 0.8-1.6% [2, 3].
It is generally accepted that the shortening of skeletal muscle
length induces a larger reduction of muscle mass, compared with a stretched skeletal muscle
(Booth and Kelso, 1973).
Therefore, the levels of IRS-1 phosphorylation determine the effectiveness of insulin in the process of glucose uptake in the skeletal muscle
. Araki and colleagues (4) indicated that mice with deletion of the IRS-1 gene have retardation of intrauterine and postnatal growth associated with moderate insulin resistance.
fibers can be characterized by their metabolic processes, namely oxidative and glycolytic muscles, oxidative fibers primarily use oxidative phosphorylation to generate adenosine triphosphate (ATP) (Lieber and Friden, 2002).
Inflammation is an important contributor to the pathophysiology of diseases related to skeletal muscle
The most extensively studied isoforms in skeletal muscle
are Pgc-1[alpha]-b, Pgc-1[alpha]-c, Pgc-1[alpha]4, the n-truncated splice variant NT-Pgc-1[alpha], and the full length variant FL-Pgc-1[alpha] [17-19, 21, 23, 24].
The entire human body is affected by exercise, but the most important organ activated as a result of this activity is the skeletal muscle
.9 Exercise causes reduction in blood pressure, 10 inflammatory status11 as well as improvement in blood lipid profile of an individual.12 In this regard, a class of proteins secreted by the skeletal muscle
fibres which exerts both local and systemic effects is known as myokines.
Examination of HandE stained sections of the extensor digitorum longus muscle of the control group revealed the normal structure of skeletal muscle
growth in domestic animals is directly linked to meat productivity and economic value.
Notably, diabetes mellitus is associated with various health problems including decline in skeletal muscle
The award, presented by the American Federation for Aging Research with support from the Irene Diamond Fund, will provide $120,000 in research funding to Ahn, a postdoctoral fellow studying age-related skeletal muscle
weakness at OMRF.
MINNEAPOLIS, Minn., July 5, 2018 -- Researchers here have developed a process to regenerate skeletal muscle
cells in mice with muscular dystrophy using stem cells derived from a type of benign tumor known as a teratoma.
Citation: Sunny Sun Kin Chan et al., Skeletal Muscle
Stem Cells from PSC Derived Teratomas Have Functional Regenerative Capacity.
The mechanism by which dandelion extract inhibits the inflammatory response in skeletal muscle
cells remains unknown; therefore, the aim of this study was to investigate the effects of dandelion extract root on the proliferation of skeletal muscle
cells and the alleviation of lipopolysaccharide (LPS)-induced inflammatory response in vitro.