Although cases of the signet-ring cell variant are exceedingly rare, our patient's meaningful treatment response highlights our unique diagnostic approach and challenges the notion that this cancer is resistant to chemotherapy.
Primary signet-ring cell carcinoma of the urinary bladder.
Microscopic examination of both specimens revealed mucin-producing malignant cells that were compatible with metastatic mucinous signet-ring cell adenocarcinoma (figure 2).
The extreme rarity of a primary colorectal signet-ring cell carcinoma metastatic to the tonsil reflects the fact that this particular histologic type of cancer occurs in only about 1% of all cases of colorectal carcinoma.
The incidence of signet-ring cell colorectal carcinoma increased by about 4.
Signet-ring cell tumors were detected in younger patients and at a later stage than the other two types.
Additionally, the overall survival of patients with carcinomas that had signet-ring cells (6 months) appeared to be worse than that of patients with pure colloid carcinomas or mixed-mucinous ones (14 months); however, the number of cases in each subgroup was too small to derive a conclusion (P = .
Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma.
melanoma is defined as a melanoma with more than 50% of tumor cells having signet-ring-shaped nuclei because of compression by intracytoplasmic globules.
Pure primary signet-ring cell
carcinomas of the bladder are very rare and only a few case reports exist of a mixed urothelial/signet-ring cell
Primary signet-ring cell
carcinoma of the uterine cervix with long term follow-up: case report.
dagger]) By convention, signet-ring cell
carcinomas are assigned grade 3 (see later).
carcinoma (greater than 50% signet-ring cells
aggregates simulating carcinoma in colon and gallbladder mucosa.
carcinoma ([is greater than] 50% signet-ring cells