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We found that the human virus bound to [alpha]-2,6-linked sialic acid receptors, which are more common in mammals, yet retained [alpha]-2,3-linked sialic acid binding, indicating that it has dual receptor specificity; this information can be used in pandemic risk assessment of zoonotic viruses.
The low affinity to KOH/PAS proved that the mucous content lacked sialic acid residues.
These findings support the hypothesis that the sialic acid in human milk may contribute significantly to greater concentrations of gangliosides in the brains of breastfed infants and to the observed neurological and intellectual advantages of breastfeeding over formula feeding.
Terminal sialic acid can be linked in ([alpha]2-3) or ([alpha]2-6) linkage and can be assigned on guidance of the structural reporter groups [H-3.
Sialic acid comprises of a family of acetylated derivatives of neuraminic acid, which act as acute phase proteins and elevated in numerous inflammatory conditions like diabetes, cancer, and renal diseases.
Biochemical Analysis of Samples: The sample were processed and analyzed for the estimation of Glutathione (GSH) Catalases Super Oxide Dismutase (SOD) Malondialdehyde (MDA) Sialic acid and Neuraminidase by the spectrophotometric method.
Flu drugs like Tamiflu and Relenza are sialic acid mimics, and work by binding to the neuraminidase and blocking its action.
Tamiflu and another anti-influenza drug, Relenza, focus on interrupting neuraminidase's ability to help influenza detach from an infected cell's surface by digesting sialic acid, a sugar on the surface of the cell.
Total sialic acid level in urine was found to be increased (normal value: 17-243 [micro]mol/nmol; the result: 6504 [micro]mol/nmol Cr).
Sialic acid, which is a derivative of acetyl neuraminic acid, attached to non-reducing residues of carbohydrate chain of glycoproteins and glycolipids is found to be elevated in alcohol abuse (8).
Structurally, transferrin is a polypeptide with two N-linked polysaccharide chains, branched with sialic acid residues.