Thymic expression of neuroendocrine self-peptide precursors: Role in T cell survival and self-tolerance
. J Neuroendocrinol 1998;10:811-22.
The ligation of CD72 on B cells was found to down-regulate B-cell receptor-related signaling, thereby maintaining self-tolerance
of B cells reactive to Sm/RNP is somewhat distinct from that of other self-reactive B cells.
Toda, "Immunologic self-tolerance
maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25).
Our data presented here suggest that the therapeutic effect of SM-MSCs in CIA mice was paralleled by increase in regulatory [FoxP3.sup.+] T cells (Treg and Tfr) and induction of regulatory B cells (T2, MZ, and B10), both of which are essential for inhibiting dysregulated immune responses to self-antigens and are involved in self-tolerance
A loss of self-tolerance
causes autoimmunity in which the aberrant immune system attacks the healthy cells and tissues, leading to chronic inflammation.
CTLA-4 is thought to be heavily involved with self-tolerance
by modulating activity in T regulatory cells.
Thus, CTLA4 provides immunosuppressive function in modulating T-cell proliferation and plays a role in immune self-tolerance
, which can be mimicked in the maintenance of tolerance to allogeneic antigens (5-7).
Cellular and genetic mechanisms of self-tolerance
SLE and ANCA associated vasculitis including granulomatosis with polyangitis, he said, are autoimmune diseases which develop due to failure of immune self-tolerance
. This disease could be life and organ threatening.
Immune checkpoints are inhibitory receptors and their ligands, which are crucial for the maintenance of self-tolerance
(that is, the prevention of autoimmunity) and for the protection of tissues from damage when the immune system is responding to pathogenic infection or other injuries.
The outcome is to try and reinstate self-tolerance
, where an individual's immune system ignores its own tissues while remaining fully armed to protect against infection.
Citation: Patricia .E de Almeida et al.; "Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance
"; Nature Communications, 2014; 5 DOI: 10.1038/ncomms4903