red blood cell

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Related to schistocyte: target cell, microspherocyte, burr cell
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Synonyms for red blood cell

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Recent studies using a morphological red blood cell module show lower within-run, between-run, and between-observer coefficients of variation when counting schistocytes compared to the coefficients observed for manual assessment.
(a) Data set Training Validation Test Normal 728 81 203 Echinocyte 226 25 63 Dacrocyte 64 7 18 Schistocyte 546 61 152 Elliptocyte 66 7 18 Acanthocyte 120 13 33 Target cell 523 58 145 Stomatocyte 79 9 22 Spherocyte 173 19 48 Overlap 166 18 46 (a) Cells were randomly distributed 80:20 between training and test sets, respectively.
The diagnostic criteria were based on: (1) thrombocytopenia (<100 ^109/L) without other identifiable causes; (2) MAHA with schistocytes on the peripheral blood smear; and (3) high LDH.
TTP was suspected because of the haemolytic anaemia, thrombocytopenia, schistocytes on the peripheral blood film and the neurological manifestations.
A review of the peripheral blood film confirmed true thrombocytopenia, marked fragmentation of red blood cells, the extensive presence of schistocytes, polychromasia and nucleated red blood cells.
This combination indicates that the technologist should confirm a low PLT count and the possible presence of schistocytes on the peripheral smear.
The diagnosis of TTP in our study was done by demonstration of significant schistocytes (more than 1 percent) on peripheral blood film.
The blood smear showed acanthosis and schistocytes; thrombotic thrombocytopenic purpura (TTP) could not be ruled out because she had hemolytic anemia (hemoglobin, 8.8 g/dL), thrombocytopenia (88 x 1[0.sup.9]6/L), acute renal failure, seizures, and new onset fever (39[degrees]C).
Peripheral smear showed anemia with mild hypochromia, rouleaux, rare spherocytes, thrombocytopenia, mature white blood cells with toxic neutrophils, and absence of schistocytes. Computed tomography of the abdomen and pelvis showed hepatosplenomegaly and lymphadenopathy throughout the chest, abdomen, and pelvis.
(6,7) If hemolysis is confirmed, coupled with findings for anemia on the CBC, an increase in the RC, and abnormalities on the peripheral blood smear (eg, schistocytes, bite cells, spur cells), the anemia is likely of the hemolytic type.
However, ADAMTS13 level is normal in CAPS and fewer schistocytes are seen in CAPS compared to TTP and HUS [2].
His Hb was 9.9 gm/dl with a baseline of 10; MCV was 90 Fl; peripheral smear did not show schistocytes.
Day 11 # Day 40 # Day 120 # C-reactive protein, mg/L 33.0 117.0 452.0 (N < 5.0) Plasma creatinine, mg/dL 1.21 2.73 5.5 (N: 0.60-1.30) Lactate dehydrogenase, IU/L 376 722 517 (N < 250) Hemoglobin, g/dL (N: 12.2-15.0) 9.6 7.7 7.0 Coombs test NA Negative Negative Platelets count, per [micro]/L 417,000 51,000 96,000 (N: 150000-450000) Haptoglobin, g/L (N: 0.3-2.0) NA <0.1 <0.1 Schistocytes count, % of red NA 4 2 blood cells Tacrolimus trough level, ng/mL 9.0 26.5 9.9 Anti-HLA antibody screening * NA Negative Negative Complement C4, g/L (N: 0.1-0.4) NA 0.34 0.36 Complement C3, g/L (N: 0.9-1.8) NA 1.14 1.53 CMV (PCR), copies/mL Undetected Undetected Undetected # After kidney transplantation.
Normal coagulation profile, normal fibrinogen level, and absence of schistocytes in the peripheral blood film were against DIC.