No DOG1 immunoreactivity was seen in salivary duct
carcinomas, oncocytomas/oncocytic carcinomas, and myoepitheliomas in the biphasic tumor; 75% (18 of 24 cases) of adenoid cystic carcinomas and 53% (8 of 15 cases) of epithelial-myoepithelial carcinomas were positive, often showing a distinctive combined apical ductal and membranous/cytoplasmic myoepithelial staining profile.
carcinomas are similar to both intraductal and infiltrating ductal carcinomas of the breast.
On follow-up, no sign of salivary duct
stricture or fistula recurrence was observed.
p63 (Biogenesis, Cambridge, Massachusetts) immunostaining was lost at the point of transition from oncocytic epithelium to salivary duct
carcinoma (SDC) (Figure 3, E).
5) Recurrent or continuous obstruction of a salivary duct
may lead to acute or chronic sialadenitis or even to the perforation of the oral mucosa.
7) Aliments, substances or bacteria within the oral cavity might migrate into the salivary ducts
and become the nidus for further calcification.
More than 90% of all malignant mixed tumors are CaExPAs and most are high grade, with salivary duct
carcinoma; adenocarcinoma, not otherwise specified; undifferentiated carcinoma; and myoepithelial carcinoma being the most common subtypes.
0%), the pure form of this tumor was reported; in the remaining half, the giant-cell tumor component was admixed with a clearly identifiable carcinomatous element--usually salivary duct
carcinoma and less frequently carcinoma ex pleomorphic adenoma.
The antibodies are directed against salivary duct
antigen, increase in [beta]-2 microglobulin in saliva and synovial fluid, general immune abnormalities including hypergammaglobulinemia, rheumatoid factor, antinuclear antibody, anti-DNA (Deoxyribonucleic acid) antibody and increased Erythrocyte Sedimentation Rate levels have been observed (4).
These cells were also positive for androgen receptor (AR), which is typically expressed in salivary duct
The differential diagnosis of lymphoepithelial cysts includes Warthin's tumor, salivary duct
retention cyst (mucocele), dysgenetic polycystic disease of the salivary gland, and mucosa-associated lymphoid tissue (MALT) lymphoma.
Hemley JD, Seols, Dayan D, Gnepp DR 2000:'Sarcomatoid Salivary duct
carcinoma of the parotid gland: Hum Pathol: 31:208-213.
29) Authors of reports of other neuroendocrine tumors in the parotid gland have proposed that such tumors arise from neuroendocrine stem cells that have migrated to the salivary gland from the neural crest (30) or possibly from cells of the salivary duct
system that have differentiated into cells with either neuroendocrine or epithelial features.
Submandibular salivary duct
cyst mimicking an external laryngocoele.
Sialolithiasis is the most common pathology of the submandibular gland, as 80% of all salivary duct
calculi form in the submandibular (Wharton's) duct.