The article, entitled "Thermal Stability and Epitope Integrity of a Lyophilized Ricin Toxin
Subunit Vaccine," is published in the journal Vaccine online and is available here.
The European Commission has granted orphan drug designation to Soligenix's recombinant modified ricin toxin
A-chain subunit (the active pharmaceutical ingredient in RiVax) for the prevention of ricin poisoning, it was reported on Monday.
Magun, "Pulmonary inflammation triggered by ricin toxin
requires macrophages and IL-1 signaling," Journal of Immunology, vol.
The Defense Appropriations Act allocation of $11 million is for separate specific, complementary research to develop therapeutic agents against Ebola, Marburg and dengue viruses, as well as to develop countermeasures for anthrax exposure and antidotes for ricin toxin
Tetracore manufactures the BioThreat Alert test strips for infectious agents and toxins, including anthrax, plague, tularemia, botulinum toxin, ricin toxin
and SEB toxin.
Like the natural ricin toxin
, the altered protein stimulates the body to make antibodies.
(AMEX:DOR) and a subsidiary of Cambrex Corporation (NYSE:CBM) have successfully achieved, ahead of schedule, the first milestone of fermentation and downstream process development in their development and manufacturing agreement for RiVax(TM), DOR's ricin toxin
Our biodefense products in development are bioengineered vaccines designed to protect against ricin toxin
and botulinum toxin, both of which are considered serious bioterrorism threats.
The vaccine candidate, which is being developed with the university, is a modified subunit of the native ricin toxin
that has been genetically engineered to eliminate both its enzymatic activity and its ability to induce vascular leak syndrome.
. In: Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare.