is known to reduce inflammation, reduce phospholipase A2, and upregulate p53.
As for quinacrine
, about two-thirds of patients who fail hydroxychloroquine or chloroquine will have a positive response to quinacrine
if added (Br J Dermatol.
For example, quinacrine
is a fluorescent acridine derivative that stains peptide-bound ATP found in high concentrations in intracellular granules (Irvin and Irvin, 1954: Bodin and Burnstock, 2001).
One case received quinacrine
following treatment failure of metronidazole.
(6) minocycline), antineoplastic agents (Bleomycin, mitoxantrone), quinacrine
. (7), silver nitrate.
(9) Another treatment option is quinacrine
HC1, which has been used for treatment of Atoxoplasma and Plasmodium, at 5-10 mg/kg PO q24h for 7-10 days; however, chloroquine and primaquine are preferred, as overdose of quinacrine
HC1 can cause hepatotoxicity.
However, such early attempts were based on conventional cytogenetic (5) or staining (e.g., quinacrine
staining for male cells) (6, 7) methods.
Volunteers provided free quinine and quinacrine
tablets every 7 days to febrile citizens (1,2).
Newer methods of sterilization include the Essure device, described later in the article, as well as the controversial quinacrine
, which has been used to sterilize women in India, Pakistan, Indonesia, and Vietnam.
Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine
. Mol Reprod Dev.
While changing medical theories and rural conditions that differed from well-controlled plantation spaces encouraged researchers to shift their focus away from bodies to mosquito ecology, in practice quinine and newly developed synthetic substitutes such as quinacrine
remained the technique of choice.
Standard of care currently includes sun avoidance, topical as wells as intralesional steroids, antimalarials, including combining hydroxychloroquine or chloroquine with quinacrine
, monitoring with cutaneous lupus disease area and severity index (CLASI) to allow for standardized assessment of skins disease activity and damage, low dose oral steroids, as well as MTX, AZA, MMF and belimumab.
Curaxins include CBL0137, which is a carbazole and CBL0102, which is a quinacrine