Bleeding in patients with FV inhibitors may be difficult to treat, since FV inhibitors interfere with the prothrombinase
complex and are difficult to bypass with currently available coagulation factor concentrates.
Comple ment proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase
The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase
complex by a novel nonenzymatic mechanism.
Similar to rivaroxaban, apixaban binds both to free factor Xa and to factor Xa in prothrombinase
Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase
This includes but is not limited to liver disease or failure, dilutional coagulopathy from massive red blood cell transfusion, severe disseminated intravascular coagulation (DIC) refractory to prothrombinase
complex concentrates or cryoprecipitate, warfarin overdose, and vitamin K deficiency.
The catalytic complex TF-VIIa activates factor X to factor Xa, leads to prothrombinase
activity on the TF-bearing cell surface and ultimately drives the thrombin to burst, which cleaves fibrinogen to fibrin, thus initiating the formation of the fibrin meshwork critical for secondary coagulation and clot stabilization.
Prothrombin (PT) is a protein synthesized from the liver with the effect of vitamin K and converted to thrombin by prothrombinase
complex in the course of coagulation.
Once the prothrombinase
complex has formed, Factor II is activated, fibrinogen is converted to fibrin, and clotting time of the sample can be measured.
Factor II (prothrombin) is a coagulation factor that is transformed into thrombin after its activation by the prothrombinase
complex at the site of vascular injury.
components can accelerate tissue plasminogen activator-catalyzed plasminogen activation.
PS exposed on the surface of erythrocytes provides a site for the assembly of the prothrombinase
and tenase complex, leading to efficient thrombin generation and ultimately to clotting (Zwaal et al.
0 reduces the action of rVIIa and the activity of the rVIIa/TF and prothrombinase
complex significantly (31).
Fibrinogen leaks into Bowman space and is broken down into fibrin by prothrombinase
, which is associated with activated monocytes.