prothrombinase


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Related to prothrombinase: Stuart-Prower factor
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Synonyms for prothrombinase

coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors

References in periodicals archive ?
Bleeding in patients with FV inhibitors may be difficult to treat, since FV inhibitors interfere with the prothrombinase complex and are difficult to bypass with currently available coagulation factor concentrates.
Comple ment proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.
The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism.
Similar to rivaroxaban, apixaban binds both to free factor Xa and to factor Xa in prothrombinase complex (17).
This includes but is not limited to liver disease or failure, dilutional coagulopathy from massive red blood cell transfusion, severe disseminated intravascular coagulation (DIC) refractory to prothrombinase complex concentrates or cryoprecipitate, warfarin overdose, and vitamin K deficiency.
The catalytic complex TF-VIIa activates factor X to factor Xa, leads to prothrombinase activity on the TF-bearing cell surface and ultimately drives the thrombin to burst, which cleaves fibrinogen to fibrin, thus initiating the formation of the fibrin meshwork critical for secondary coagulation and clot stabilization.
Prothrombin (PT) is a protein synthesized from the liver with the effect of vitamin K and converted to thrombin by prothrombinase complex in the course of coagulation.
Once the prothrombinase complex has formed, Factor II is activated, fibrinogen is converted to fibrin, and clotting time of the sample can be measured.
Factor II (prothrombin) is a coagulation factor that is transformed into thrombin after its activation by the prothrombinase complex at the site of vascular injury.
Prothrombinase components can accelerate tissue plasminogen activator-catalyzed plasminogen activation.
PS exposed on the surface of erythrocytes provides a site for the assembly of the prothrombinase and tenase complex, leading to efficient thrombin generation and ultimately to clotting (Zwaal et al.
0 reduces the action of rVIIa and the activity of the rVIIa/TF and prothrombinase complex significantly (31).
Fibrinogen leaks into Bowman space and is broken down into fibrin by prothrombinase, which is associated with activated monocytes.