According to the company, Hydroxyprogesterone caproate (HPC) is a progestin
indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth.
A major disadvantage of the GnRH analogue-class of medications is that they are more expensive than the progestin
medications mentioned above.
Progestin-only injectable contraception: Depot medroxyprogesterone acetate (DMPA or Depo-Provera, Pfizer) is a long-acting progestin
given as a single intramuscular injection every 13 weeks.
Although estrogen with or without progestin
lowered the risk for osteoporotic fracture, it offered no other clear benefit in terms of reducing risk for chronic disease.
Some birth control pills, called mini-pills, contain only progestin
. These pills do not always suppress ovulation, but make the cervical mucus thick and unwelcoming to sperm, preventing entry to the uterus.
In the Women's Health Initiative (WHI) randomized trial, estrogen plus progestin
was associated with an increase in both breast cancer incidence and mortality.
Comment: Endometrial hyperplasia without atypia in premenopausal women is commonly treated with a progestin
. The results of the present study suggest that genistein aglycone is an effective alternative to a progestin
in this group of women.
It is the type 1 lesions that can be protected against by the addition of progestins
in HRT, and data are accumulating about the safest means of administering the progestins
The results found health risks associated with estrogen plus progestin
persist even a few years after stopping the drugs.
"Estrogen Plus Progestin
Study Stopped Due to Increased Breast Cancer Risk, Lack of Overall Benefit." National Heart, Lung and Blood Institute.
Furthermore, the lower the dose of one particular progestin
, the lower the risk of ovarian cancer.
After years of debate about the safety of hormone replacement therapy in menopause, a major medical group last week revised its position, stating that estrogen and progestin
drugs may actually protect the hearts and bones of certain women.
Hormone replacement therapy (HRT) can mean either taking estrogen alone or taking estrogen plus progesterone or progestin
, a synthetic hormone with effects similar to those of progesterone.
in HT is included primarily to prevent buildup of the uterine lining.
The study included a subgroup of women from the estrogen alone and combined estrogen plus progestin
arms of the Women's Health Initiative (WHI).