Abbreviations: APC: apical pore complex
; BI: Bayesian inference; BS: Bootstrap support; BSA: Bovine serum albumin; BSE: Back scatter electron; CFP: Ciguatera fish poisoning; CTXs: Ciguatoxins; DNA: Deoxyribonucleic acid; LC-MS/MS: Liquid chromatography-mass spectrometry/mass spectrometry; LSU rDNA: Large subunit ribosomal DNA; ML: Maximum likelihood; MTXs: Maitotoxins; PCR: Polymerase chain reaction; Po: outer pore plate; PP: Posterior probability; SE: Secondary electron; SEM: Scanning electron microscopy; SSU rDNA: Small subunit ribosomal DNA
(2009) Evidence for a shared nuclear pore complex
architecture that is conserved from the last common eukaryotic ancestor.
The triple A syndrome is due to mutations in ALADIN, A novel member of the nuclear pore complex
. Endocrine Res.
Snapshots of nuclear pore complexes
in action captured by cryo-electron tomography.
It is mainly composed of nuclear lamina, which at the periphery, interacts with the inner nuclear membrane and is interconnected with cytoskeleton at the pore complex
. It consists mainly of intermediate filaments called lamins and microfilaments cal led act ins and DNA topoisomeraseII (Fig.1).
Recently, a group of researchers at Oxford University published a model for the structure of the nuclear pore complex
(NPC), the gatekeeper for the movement of molecules into and out of the nucleus (Alber et al., 2007a,b).
Koonin, "Comparative Genomics, Evolution and Origins of the Nuclear Envelope and Nuclear Pore Complex
," Cell Cycle 3 (2004): 1612-37.
The PB1-F2 protein localizes to the mitochondria of the infected cells (35) where it interacts with 2 components of the mitochondrial permeability transition pore complex
, ANT3 and VDCA1, that are thought to play a major role in apoptosis control (36).
Thus far, signal-mediated transport via pores has been demonstrated only for ultrafine gold particles of up to 39 nm in diameter, through the nuclear pore complex
in Xenopus oocytes, where transport velocities depended on particle size (Pante and Kann 2002).
Figure 1C shows a portion of a nucleus stained with antibodies to the nuclear pore complex
, followed by secondary antibodies that are conjugated to 0.8-nm colloidal gold particles.