Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet factor
Residual platelet factor
V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms.
This was also supported by the platelet activation factor data as given in table 1, indicating no increase in platelet factor
4 release activated by the microspheres on incubation with blood compared to untreated blood.
It is caused by heparin-dependent, platelet-activating antibodies that recognize a "self" protein, platelet factor
4 (PF4), and heparin.
HIT is a clinicopathologic condition and adverse drug reaction caused by platelet-activating antibodies of mostly pathogenic IgG class which are directed against a molecular complex formed by heparin and platelet [alpha]-granule protein, platelet factor
4 (PF4) .
Drugs induced immune destruction of platelets can be caused by two mechanisms: a drug dependent binding of Fab part of the pathological IgG with the platelets, causing their destruction, and in the second type Fab portion of the pathological IgG binds to platelet factor
It is caused by antibodies against platelet factor
For example, a small study found significantly elevated levels of platelet factor
4 among 12 depressed patients after a myocardial infarction, compared with 12 matched, nondepressed participants (Psychiatry Res.
Yet when the serum samples were tested for reactivity with antibodies, 100% of the samples reacted to platelet factor
4 bound to unfractionated heparin and to enoxaparin, but none reacted to platelet factor
4 bound to fondaparinux, Dr.
These cytokines include platelet-derived growth factor, transforming growth factor B1, platelet-derived epidermal growth factor, platelet-derived angiogenesis factor platelet factor
4, and platelet-activating factor.
We also investigated the persistence of circulating heparin-dependent antibodies by performing a platelet serotonin-release assay and an assay for anti-bodies against platelet factor
When heparin is administered to patients susceptible to HIT, an antigen complex of heparin and platelet factor
4 (PF4) is formed.
The researchers insert into the virus the gene for platelet factor
4 (PF4), a substance that stops the growth of blood vessels.
The mechanism is that platelets can release platelet factor
4 which could inhibit the function of heparin.
(PF4) kit and Asserachrom PF4, was from Diagnostica Stago, France.