plasmin


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Related to plasmin: plasminogen, fibrinogen
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Synonyms for plasmin

an enzyme that dissolves the fibrin of blood clots

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Thus its proved that plasmin induced posterior vitreous detachment and vitreolysis has as good an effect as induced by pars planavitrectomy, with no surgical complications10.
Plasminogen activators are able to release plasmin, and the plasmin-like enzymes directly degraded the fibrin, leading to the rapid and complete destruction of the thrombi (Kotb, 2013).
As a synthetic antifibrinolytic agent, it can competitively inhibit the activation of plasminogen and noncompetitively inhibit the plasmin activity at high concentrations.[6] Consequently, TXA can reduce the blood loss by decreasing the conversion of plasminogen into plasmin, an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins including procoagulant factors 5 and 8.[7] TXA has been proven to be effective in reducing TBL and transfusions after TKA by different methods without risk of complications.[6],[8],[9],[10],[11] The most commonly reported administration methods included intravenous (IV) and topical administration.[12] Moreover, there is no difference in efficiency and safety between IV or topical administration.
Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface.
Two of the primary antigens are the nephritis-associated plasmin receptor (NAPIr) [10] and the streptococcal pyrogenic exotoxin B (SPEB) [11].
In addition to these strategies, there is a new recommendation for managing refractory PPH: tranexamic acid, which works by binding to lysine receptors on plasminogen and plasmin, inhibiting plasmin-mediated fibrin degradation.
Activated plasminogen, plasmin, is a fundamental component of the fibrinolytic system and is the main enzyme involved in the lysis of blood clots and clearance of extravasated fibrin.
Under normal physiological conditions of the human body, fibrin mesh is sliced by an enzyme plasmin (EC 3.4.21.7), releasing various fibrin degradation products (1,2).
Tranexamic acid (TXA) is a reversible antifibrinolytic agent that completely blocks the conversion of plasminogen to plasmin. TXA inhibits the proteolytic action of plasmin on the fibrin clot and prevents thrombolysis, rather than the formation of a new clot.
Tranexamic acid (Trans-4-aminomethylcyclohexanecarboxylic acid) [TNA], is a plasmin inhibitor used to prevent abnormal fibrinolysis to reduce blood loss.11 It is a synthetic lysine derivative and blocks lysine binding sites on plasminogen molecules, preventing conversion of plasminogen to plasmin.
She had sinus tachycardia on electrocardiography, higher values of serum dimerized plasmin fragment D (D-dimer) (5000 ng/mL) and an enlarged pulmonary artery with mild cardiomegaly on the chest X-ray.
In addition, complementary PR3 can also be found in AAV, especially in those with PR3-ANCA.5 Complementary PR3 targets plasminogen, hence delay the conversion of plasminogen to plasmin. With increasing dissolution time of fibrin clots, complementary PR3 will result in a higher incidence of VTE.
Your body produces plasmin, an enzyme that degrades fibrin clots.
TA is a synthetic lysine analog that is a competitive inhibitor of plasminogen and plasmin, inhibiting fibrinolysis by preventing conversion to plasmin (Haspl, Oremus, Sostaric, & Trkulja, 2014; Wei & Liu, 2015).
Amniotic fluid embolism syndrome is that amniotic fluid that contains a complex mixture of maternal extracellular fluid, foetal urine, foetal squamous cells, lanugo hair, vernix caseosa, mucus, meconium, foetal antigens and potent vasoactive components such as thromboplastin, plasmin activator, vasoconstrictor endothelin, platelet activating factor, prostaglandin F2[infinity] (a potent pulmonary vasoconstrictor) and endogenous mediators like histamine, bradykinin, endothelin, leukotriene and arachidonic acid metabolites.