Five of eight studies with 63-111 patients each showed that adding the antihypertensive [beta]-blocker pindolol
to treatment with an SSRI accelerated the antidepressant response, a 2001 analysis found.
High-performance liquid chromatographic analysis of pindolol
enantiomers in human serum and urine using a reversed-phase cellulose-based chiral column.
Effectiveness of pindolol
with selected antidepressant drugs in the treatment of major depression.
is effective in patients with vasovagal syncope.
The serotonin receptor antagonists spiroxatrine (5-H[T.sub.1A]), pindolol
(5-H[T.sub.1B]), ritanserin (5-H[T.sub.2]) and ICS 205-930 (5-H[T.sub.3]) attenuated the spinal analgesic effects of morphine (Basbaum and Fields, 1985).
Later-generation b-blockers (metoprolol, atenolol, pindolol
, carvedilol, and sotalol) should be used to minimize the potential for fatigue.
Among [beta]blockers, propranolol and timolol have good evidence of efficacy, but drugs such as pindolol
and acebutolol have limited evidence of efficacy.
MADRID -- The [beta]-blocker pindolol
enhances the efficacy of certain antidepressants but in a strictly time-limited fashion, Dr.
Conventional drugs used were oral atenolol 50 mg, metoprolol 100 mg, pindolol
5 mg, or fixed-ratio hydrochlorothiazide 25 mg plus amiloride 2.5 mg, all given once daily.
The combination of pindolol
and digoxin reduced the maximum area under the heart rate curve significantly more than verapamil and digoxin. Finally, the combination of amiodarone and digoxin slowed the resting heart rate when compared with baseline, while the combination of quinidine, verapamil, and digoxin did not; this was a small trial, however, and the baseline resting heart rates were not rapid.
Comparative tolerability of labetalol versus propranotol, atenolol, pindolol
, metoprolol and nadolol.
Belzung, "Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol
," European Journal of Pharmacology, vol.
The following drugs were used: (i) acetylsalicylic acid (ASA), apamin, atropine, bradykinin, caffeine, capsaicin, capsazepine (CAPZ), charybdotoxin, glibenclamide, haloperidol, L-glutamic acid, phorbol 12myristate 13-acetate (PMA), pindolol
, tetraethylammonium chloride, and yohimbine were purchased from Sigma-Aldrich (St.
Shibutani et al., "An echocardiographic study of interactions between pindolol
and epinephrine contained in a local anesthetic solution," Anesthesia Progress, vol.
* Sympathomimetic drugs (partial agonists), such as Pindolol