drugs may also cause pseudoporphyria (skin lesions similar to porphyria cutanea tarda), e.
Furthermore, taking antihypertensive drugs of unknown photosensitizing
potential conferred a 10% increase in risk of cSCC in the study.
Therefore, the photosensitizing
AQ1 could be an alternative for the Candida infections treatment, which deserves further investigation.
21 mm) compared with SRP alone, although the ADA found a moderate level evidence supported the use of the PDT DL in conjunction with a photosensitizing
10) Other factors implicated in etiopathogensis are exposure to sunlight, (7,8) photosensitizing
medications, (6) mild ovarianor thyroid dysfuntion (10) and certain cosmetics.
PDT is performed by first administering to the patient a photosensitizing
agent, which is usually given intravenously but can also be given orally or applied topically.
The photoinsecticidal effect steadily increased with increasing the concentration of the photosensitizing
agent in the bait.
First, patients receive an intravenous injection of a photosensitizing
Photosensitive dermatitis occurs when photosensitizing
substances (photodynamic agents) are present in sufficient concentration in skin and are exposed to light (Radostits, 2007).
For photodynamic therapy, a photosensitizing
agent is applied to the cervix and accumulates in the premalignant cells, he explained.
Psoralens are a group of photosensitizing
drugs which are ineffective when used alone, but in combination with UVR provide an effective tool for the treatment of psoriasis and a number of other photoresponsive skin disorders e.
Clearly, a precise knowledge of the active sites where drugs can interact with biomolecules and the involved reaction mechanisms would contribute to understanding the photosensitizing
potential of new drug candidates.
AKs are commonly treated with cryotherapy (freezing) and, more recently, with photodynamic therapy--which uses laser light and a photosensitizing
topical drug to kill cancer cells--or topical medications such as fluorouracil or imiquimod, which require weeks to months of use and can cause skin irritation during this time.
circularisquama is suspected to produce as many as 3 toxins, one of which, purified and labeled H2-a, has shown both potent photosensitizing
cytotoxic activity against HeLa cells and hemolytic activity in rabbit erythrocytes (Miyazaki et al.
Photodynamic therapy involves free-radical oxygen release when a photosensitizing
compound is administered systemically and activated by a light of a specific wavelength.