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TEHRAN (FNA)- Age-related macular degeneration could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, new research suggests.
Our research has demonstrated the feasibility of restoring visual responses after the loss of light-sensitive photoreceptor cells in animal models," said Pan.
In examining controls and exposed mice at postnatal day 60, the researchers found that late-born rod photoreceptors and rod and cone bipolar cells increased by 16-30% in exposed offspring, whereas Muller glial cells (also classified as late-born retinal cells) did not increase.
Light waves that are too short [ultraviolet] or too long [infrared] are not detected in our photoreceptors," says Ribak.
Vertebrates use ciliary opsin in photoreceptor cells, whereas invertebrates use rhabdomeric opsin.
The study, backed by the Medical Research Council and reported in the magazine Nature, is the first showing photoreceptor transplants are possible.
A team from University College London and Moorfields Eye Hospital, London, experimented on mice that had suffered from photoreceptor loss which damages the retina but leaves the wiring to the brain intact.
Abstract--Retinal prosthetics are designed to restore functional vision to patients with photoreceptor degeneration by detecting light and stimulating the retina.
Introduction: Rods and cones are classically described as distinct photoreceptor cells with different receptive characteristics mediated by distinct opsins, but recent studies show that salamander blue-sensitive cones and green rods both express an identical opsin.
Optical MEMS devices could eventually eliminate the need for high-cost precision manufacturing of components that stabilize movement in Xerox photoreceptor belts.
Studies at the University's Central Institute for the Deaf (CID) have resulted in the first successful transplantation of photoreceptor tissue into blind eyes, according to researchers whose findings were published in the August issue of Investigative Ophthalmology and Visual Science.
KYOTO, Japan -- Kyocera Corporation (NYSE:KYO)(TOKYO:6971) today announced the availability of its KYOCERA Mega Surface Series amorphous silicon (a-Si) photoreceptor drum, which offers record durability as a core component in electrophotographic printing equipment -- including laser printers and multifunctional products (MFPs).
The findings come from a study by an international team of scientists, including researchers in Oxford, Sheffield and London, which showed that gene therapy can provide long-term protection for photoreceptor cells in an animal model of retinitis pigmentosa.
The results indicate that their brains can still "see", or detect, light via a novel photoreceptor in the ganglion cell layer of the retina, different from the rods and cones we use to see.
Due to a genetic mutation, the retinas of these recipient mice quickly degenerate, the photoreceptor cells die and at the time of transplant electrical activity, as detected by ERG (electroretinography), is absent.