1997) conducted a randomized double-blind controlled trial to study the effectiveness of an antihistamine-decongestant (brompheniramine maleate 2 mg/5 ml and phenylpropanolamine
Exclusion criteria included: 1) a diagnosis of diabetes, 2) body weight change of [+ or -] 4 kg in the 6-months prior to the study, 3) incapable of engaging in physical activity, and 4) use of monoamine oxidase inhibitors, beta-blockers, alpha-1 adrenergic inhibitors, or weight loss products or decongestants that contained phenylpropanolamine
FDA, Review of Study Protocol, Final Study Report and Raw Data Regarding the Incidence of Hemorrhagic Stroke Associated with the Use of Phenylpropanolamine
2, at www.
As of last September there were about 1,900 SKUs with pseudoephedrine, ephedrine or phenylpropanolamine
for sale and more than 131,000 registered sellers nationwide.
Examples of common ingredients in cough and cold medications, by class of medication Class Examples Antihistamine Acrivastine, brompheniramine, carbinoxamine, (first generation) chlorpheniramine, cyproheptadine, diphenhydramine, doxylamine, triprolidine Antipyretic Acetaminophen, ibuprofen and analgesic Cough suppressant Benzonatate, codeine, dextromethorphan, (antitussive) hydrocodone Expectorant Guaifenesin Nasal decongestant Ephedrine, phenylephrine, phenylpropanolamine
Title VII of the Act contains subtitles concerning regulation of domestic and international commerce in three methamphetamine (meth) precursor chemicals: ephedrine, pseudoephedrine, and phenylpropanolamine
(EPP); increased penalties for methamphetamine offenses; expanded environmentally-related regulations; and adjusted grant programs.
Popular drugs such as Claritin D and Advil Cold and Sinus - and their generic equivalents - that contain pseudoephedrine, ephedrine or phenylpropanolamine
now require a prescription and are classified as controlled substances under a new state law that took effect today.
MDMA was identified by GC with nitrogen-phosphorus detection (Barnes-Jewish Hospital Drug Analysis Laboratory), and phentermine, chlorpheniramine, and phenylpropanolamine
were identified by GC/MS (Mayo Medical Laboratories).
Both types of products increase heart rate to a small degree, Unlike its cousin phenylpropanolamine
, pseudoephedrine rarely causes large increases in blood pressure, although its effect on blood pressure is dose-related and a marked effect could occur with overdose.
4569 HANNON Requires businesses selling products containing ephedrine, pseudoephedrine or phenylpropanolamine
to store such products either behind a counter in an area accessible only to personnel of such business, or in a locked container.
Drugs used in the past, such as thyroid hormone, dinitrophenol, amphetamine, fenfluramine, phenylpropanolamine
, and ephedra are well known for significant complications, including death.
The requirements relating to the marketing, sale, or distribution of ephedrine, pseudoephedrine, or phenylpropanolamine
products supersede any local ordinance or regulation passed by a county, municipality, or other local governmental authority.
Over-the-counter cold and allergy products containing the decongestant phenylpropanolamine
(PPA) were removed from the marketplace in November 2000, based on FDA concerns over the propensity of this particular decongestant to lead to strokes, particularly hemorrhagic strokes.
For instance, the director of the Federal Judicial Center, Judge Barbara Rothstein, has retained jurisdiction of the phenylpropanolamine
(PPA) MDL in Seattle.
In a recent health feature, `Scare@yourinbox' (21 Sept) we wrote Alka-Seltzer, Day Nurse, Sinutab and Sudafed contain an ingredient, phenylpropanolamine
(PPA), which had been linked to strokes and banned in the US.