There are substantial--more than 900 --human pregnancy exposures in the first trimester with phenazopyridine
Four different regimens were used for intraoperative ureteral evaluation: 1) oral phenazopyridine
200 mg, 2) intravenous sodium fluorescein 25 mg, 3) mannitol bladder distention, and 4) normal saline bladder distention.
Red/pink: UTIs; enlarged prostate; tumors; kidney cysts; long-distance running; kidney or bladder stones; the use of medications such as rifampin (Rifadin, Rimactane) or phenazopyridine
(Pyridium); the use of some laxatives; the use of chemotherapy drugs.
of cases (n) Percentage (%) Recovered 78 65 Recovering 9 8 Continuing 11 9 Loss to follow up 22 18 Total 120 100 Figure 11: Percentage Paracetamol 12 Diclofenac 6 Domperidone 1 Ondansetron 2 Dicycloverine 10 Pantoprazole 11 Terazosin 5 Doxazosin 4 Finasteride 3 Estogen and progesterone (HRT) 5 Insulin 2 Metformin 9 Metformin + Glimepiride 4 Glimepiride 1 Sitagliptin + Glebenclamide 7 Disodium hydrogen citrate 14 Phenazopyridine
Hyrochloride Note: Table made from bar graph.
Interference by phenazopyridine
with the leukocyte esterase dipstick.
Nine of 30 patients complained of mild to moderate frequency, and five of dysuria, which settled within 1-2 weeks with anticholinergics and phenazopyridine
Over-the-counter medications that contain phenazopyridine
, such as Uristat and AZO, can relieve pain and burning, but they can't cure the infection (and they turn urine an orange-red color, so don't be alarmed if this occurs).
Medications Associated with Changes in Urine Color Color of urine Medications red senna (Ex-Lax), chlorpromazine (Thorazine), thioridazine (Mellaril) orange rifampin (Rifadin), warfarin (Coumadin), phenazopyridine
(Pyridium) blue or green amitriptyline (generic), indomethacin (Indocin), cimetidine (Tagamet), promethazine (Phenergan) dark brown or tea-colored chloroquine (Aralen), primaquine (generic), metronidazole (Flagyl), nitrofurantoin (Furadantin)
Common causes of acquired methaemoglobinaemia Acetanilid Naphthoquinone p-amino salicylic acid Naphthalene Aniline dyes Nitrites Benzene derivatives Nitroglycerin Clofazimine Nitric oxide Chlorates Nitrobenzene Chloroquine Paraquat Dapsone Phenacetin Local anaesthetic agents Phenazopyridine
Metoclopramide Primaquine Methylene blue (paradoxically can transiently Sulfonamides worsen methaemoglobinaemia)
The human data for phenazopyridine
are limited, but there is no evidence that this drug produces toxicity in the embryo or fetus.
AZO Standard, an over-the-counter (O-T-C) urinary pain reliever containing phenazopyridine
hydrochloride, the No.
Figure 3 shows the result of the evaluation of aqueous solubility at four different pHs for phenazopyridine
and piroxicam samples.
The chronic use of phenazopyridine
accounted for all of these findings.
Other commonly used and helpful nonspecific treatments include urinary analgesics to reduce bladder pain such as phenazopyridine
hydrochloride (Pyridium), anticholinergic/antispasmodic therapies (Ditropan, Detrol, Levbid) to decrease frequency and urgency, and on occasion muscle relaxants such as Valium and Flexeril to reduce pelvic floor muscle spasticity.
5] deficiency, M Hb, unstable Hb Drug/chemical induced Acetaminophen, amyl nitrite, benzocaine, dapsone, nitroglycerin, nitroprusside, phenazopyridine
(pyridium), sulfanilamide, aniline dyes, chlorates, nitrofurans, sulfones Diet induced Nitrites, nitrates (a) Adapted from Mansouri and Lurie (1993).