Extracted samples were centrifuged at 10, 000 rpm for 10 min at 4 [degrees]C and supernatant were analyzed for penicillin V production.
Different temperatures like 23, 26 and 30 [degrees]C were used the production of penicillin V and monitored for seven days.
(31) The impact of [beta]-lactamase production in cases of penicillin failure is suggested by a recent study of 20 children with recurrent pharyngotonsillitis after penicillin V therapy.
(5,35) In a recent study of 40 children with recurrent tonsillitis, AHS was recovered significantly less often following treatment with penicillin V than with cefdinir (30% vs 75%; P = 0.01).
Thirty-three [beta]-lactamase--producing bacterial organisms--predominantly Staphylococcus aureus, Haemophilus influenzae, and Moraxella catarrhalis--were recovered from 17 (85%) of those treated with penicillin vs
. 4 organisms isolated from 3 patients (15%) treated with cefdinir.
Their throats were swabbed for both a rapid antigen test and culture, and they were randomly assigned to a 10-day course of either 750 mg amoxicillin once per day or 250 mg penicillin V 3 times per day.
Whether 10-day treatment with once-daily amoxicillin is as effective as penicillin V in preventing suppurative and nonsuppurative complications remains unanswered.
The treatment failure rate was 35% among 285 children who received a standard 10-day course of oral penicillin V
and 37% of 271 who were given standard intramuscular benzathine penicillin G, Dr.
Five vs ten days of penicillin V
therapy for streptococcal pharyngitis.
The earlier prophylactic trial of penicillin vs
. placebo in 39 children showed no difference in the number of GABHS infections acquired during an 8-month period.