Klaewsongkram, "Alkali-treated penicillin G
solution is a better option than penicillin G
as an alternative source of minor determinants for penicillin skin test," Allergy and Asthma Proceedings, vol.
Two multicenter, randomized, single-blind studies conducted in 1994 and 1995 reported that 35% of children aged 2 to 12 years treated with oral penicillin V and 37% treated with intramuscular benzathine penicillin G had a positive throat culture result for a concordant serotype of GABHS when tested either 10 to 14 days or 1 month after starting treatment (FIGURE 2).
(3) If patient compliance with an initial oral penicillin regimen was poor, then consideration may be given to the use of intramuscular benzathine penicillin G. IDSA guidelines recommend second- or third-generation cephalosporins for use in patients who fail first-line therapy with penicillin or amoxicillin.
A nationwide survey of 481 infectious disease specialists showed that 76% had experienced shortages of intravenous penicillin G since Sept.
The situation concerning penicillin G is "alarming," according to the Infectious Diseases Society of America, which conducted the survey.
For a few conditions (e.g., congenital syphilis and neurosyphilis, and intrapartum prophylaxis for perinatal group B streptococcal disease), intravenous penicillin G
is the drug of choice.
of Broomfield, Cola., will provide limited supplies of penicillin G sodium from the Austrian firm Biochemie GmbH under an emergency allocation program, the Food and Drug Administration announced in late January.
Physicians treating neurosyphilis, congenital syphilis, invasive group A streptococcal disease, or leprosy may purchase intravenous penicillin G on an "urgent need" basis, said Elizabeth Wheeler, director of communications for Geneva Pharmaceuticals.
The patient was empirically started on penicillin G
, and cefotaxime was added shortly thereafter because of the possibility of intermediately resistant pneumococcus.
The treatment failure rate was 35% among 285 children who received a standard 10-day course of oral penicillin V and 37% of 271 who were given standard intramuscular benzathine penicillin G
pneumoniae with reduced susceptibility to penicillin G
increased from 3.8% in 1987 to 48% in 1997 (12).
For example, penicillin G
in appropriate doses is often effective therapy for drug-resistant Streptococcus pneumoniae pneumonia.
Evaluation of penicillin hypersensitivity: value of clinical history and skin testing with penicilloyl-polylysine and penicillin G
. J Allergy Clin Immunol 1977; 60:339-45.
Evaluation of benzathine penicillin G
. N Engl J Med 1954; 251:466-71.