Second, in addition to chelating copper, penicillamine
chelates mercury and lead and removes them from the body.
In addition, for our patient who requires penicillamine
for his hepatolenticular degeneration, we suggest using zinc as a substitute.[sup]
Other drugs responsible for this pattern include immunosuppressive agents (penicillamine
), antibiotics (sulfasalazine, nitrofurantoin) and NSAIDS.
The radiochemical purity of the complex was 99.6% when 1.0 mg ciprofloxacin in the presence of 100.0 g SnCl2, 2.0 mg gentistic acid, 3.0 mg penicillamine
and 20.0 mg d-mannitol was labeled by 10-20 mCi sodium pertechnetate.
Several medications have been known to induce scleroderma-like clinical conditions including bleomycin, docetaxel, and penicillamine
. (12) In addition, one case report described SSc possibly induced by interferon alpha and interleukin 2 (IL-2) treatment in a patient with metastatic melanoma.
(16) Some of the other medications that have been tested as a single agent in the treatment of PBC include chlorambucil, penicillamine
, cyclosporine, corticosteroids, azathioprine, mycophenolate mofetil, thalidomide, methotrexate, malotilate, and colchicine.
Chelating agents, such as penicillamine
(Cuprimine[R]) and gold compounds, such as auranofin (Ridaura[R]) are used to decrease inflammation and to slow the destruction of joint tissue.
Only two of the drugs (ethanol and penicillamine
) are known to cause embryo or fetal harm but, for most of these drugs, the reported human pregnancy experience is very limited or absent.
We found that complex (I), the synthesis and composition of which are described [14,21], evolves NO and penicillamine
thiolyl upon decomposition .
A formal analysis of estimated continuation of 1,083 courses of six DMARDs over 60 months in 477 patients with RA indicated that approximately 80% of MTX courses were continued after 2 years, compared to 50% of courses of hydroxychloroquine, penicillamine
, parenteral gold, and azathioprine and only 20% of courses of oral gold.
Guedon, "Inhibition of experimental esophageal lye strictures by penicillamine
," Archives of Otolaryngology, vol.
The possibility of an autoimmune etiology in some patients with IS was suggested by its association with myasthenia gravis, thymoma, Addison's disease, vitiligo, Hashimoto's thyroiditis, vitamin B12 deficiency, coeliac disease, rheumatoid arthritis, and penicillamine
The pharmacological agent which are selected for evaluating in this study is Penicillamine
, which their selection rationale will be discussed in detail separately in the following sections.
The drugs--including Plaquenil (hydroxychloroquine), Cuprimine (penicillamine
), Remicade (infliximab) and Azulfidine (sulfasalazine) --can be used singularly or in combination.
These include abatacept, adalimumab, anakinra, azathioprine, cyclophosphamide, cyclosporine, etanercept, gold, hydroxychloroquine, infliximab, leflunomide, methotrexate, minocycline, penicillamine
, rituximab, and sulfasalazine.