associated with follicular dendritic cell sarcoma: report of a case and review of literature.
affects both genders and can occur at any age.
Comparative study of five serological assays for the diagnosis of paraneoplastic pemphigus
. Pathology 2015;47:58-61.
with fatal pulmonary involvement in a woman with a mesenteric Castleman tumour.
Generalized involvement of several nodes accompanied by systemic involvement is called as multicentric type of CD.8 Uncommon sites of involvement are oropharynx, nasopharynx, pericardium and soft tissues.10 The etio-pathogenesis remains uncertain but there are various hypotheses such as overproduction of IL-6, infection with human herpes virus8, functional block of plasmacytoid monocytes, autoimmunity and dysplasia of follicular dendritic cells.2-4 There are some clinicopathologic conditions that might be associated with CD; paraneoplastic pemphigus
, Kaposi\'s sarcoma, Hodgkin\'s lymphoma, nephrotic syndrome, temporal arteritis, myasthenia gravis, recurrent pleural effusion and FDCS.4
We present a patient with paraneoplastic pemphigus
(PNP) in whom the clinical suspicion of bronchiolitis obliterans (BO) was raised when the patient suffered respiratory failure and difficulty in weaning from mechanical ventilation.
Conditions with a presentation similar to SIS/ TEN include erythema multiforme, erythematous drug reaction, pustular drug eruptions, sunburn, toxic shock syndrome, staphylococcal scalded skin syndrome, and paraneoplastic pemphigus
Of these, oral lesions are commonly seen in Pemphigus vulgaris (PV), Paraneoplastic Pemphigus
(PNP), and Pemphigus associated with inflammatory bowel disease.
* Paraneoplastic Pemphigus
. Painful erosions of the vermilion border and mucosal involvement are characteristic of this paraneoplasia.
Auto-immune blistering diseases include pemphigus vulgaris, paraneoplastic pemphigus
, bullous pemphigoid, cicatricial pemphigoid, dermatitis herpetiformis, and linear IgA dermatosis.1