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toxic to the organs of hearing or balance or to the auditory nerve

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References in periodicals archive ?
Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo.
The prevalence of the A1555G mutation was shown to be between 20-30 per cent in deaf individuals in Spain and Asia of which 15 per cent of them had the history of aminoglycoside ototoxicity (85).
The mechanism of platinum ototoxicity is mediated by free-radical production and cell death.
Cisplatin and oxaliplatin toxicity: Importance of cochlear kinetics as a determinant for ototoxicity. Journal of the National Cancer Institute, 101(1), 37-47.
Other more serious adverse effects of cisplatin include nephrotoxicity, peripheral neuropathy, acute bone marrow suppression, and ototoxicity (CureSearch et al., 2008; Lehne, 2007; Li, 2006; Mayo Clinic, 2008).
Although one-third of all FDA approved drugs are associated with hearing loss or tinnitus as possible side-effects, the potential for ototoxicity is both well-documented and not adequately addressed.
Unfortunately, platinum-based therapies cause ototoxicity in many patients, and are particularly harmful to the survivors of pediatric cancer.
The European Medicines Agency has accepted on the 28th of June 2019 the Pediatric Investigation Plan for both developments in the treatment of severe sudden sensorineural hearing loss (SSNHL) and for prevention of ototoxicity caused by cisplatin in pediatric populations.
The European Medicines Agency (EMA) has accepted France-based Sensorion's (Paris:ALSEN)(FR0012596468 - ALSEN) Pediatric Investigation Plan (PIP) for both development in the treatment of severe hearing loss and for prevention of ototoxicity caused by cisplatin in the paediatric population, it was reported yesterday.
He added that besides a baby going to ICU after delivery and receiving the ototoxicity drug, there are other causes of hearing loss.
In some studies, it was shown that several mercuric compounds cause ototoxicity in systemic administration [3-6].
Prevention of treatment-induced ototoxicity: An update for clinicians
Head and neck cancer survivors have unique treatment needs and distresses, including persistent and late effects of treatment, such as disfigurement and body image issues, swallowing difficulty, ototoxicity and depression.
We conducted an animal experiment to assess the effect of adding pentoxifylline to amikacin to prevent amikacin-induced ototoxicity. This research was conducted on 24 rats arranged in four groups of 6.
On the other hand, streptomycin did not show good CSF penetration in the absence of inflammation10 and serious adverse events like nephrotoxicity and ototoxicity are associated with it.