Adults with osteomalacia
might suffer from widespread bone pain and muscle weakness, particularly in the vertebrae, when vitamin D concentrations drop to 12 ng/mL or less.
Given the patient's clinical presentation, history of low-trauma fractures, hypocalcemia, persistently increased serum alkaline phosphatase, and evidence of secondary hyperparathyroidism, the primary diagnosis was identified as osteomalacia
, caused by chronic malabsorption of calcium and vitamin D in the setting of a prior RYGB and further exacerbated by chronic proton pump inhibitor use.
In women, adequate intake of vitamin D, calcium, and vitamin K reduce the risk of osteoporosis (low bone mass) and osteomalacia
(bone softening), two conditions that raise your risk of fractures.
Rickets and osteomalacia
. Medicine 2009; 37: 483-8.
A lack of vitamin D can lead to bone deformities such as rickets in children and bone pain caused by a condition called osteomalacia
Helliwell et al14 in Bradford revealed high levels of persistent pain biochemical osteomalacia
, and disability especially amongst immigrants from Mirpur area of Pakistan, which was unrelated to diagnosis, biochemical status or treatment with calcium or vitamin D.
Vitamin D deficiency can lead to a range of complications, including a condition called osteomalacia
, which makes bones soft, painful and more likely to break.
The following search terms were used: "vitamin D" or "vitamin D supplementation" or "cholecalciferol" or "25-hydroxyvitamin D" or "VDR knockout" or "1a-hydroxylase deletion" or "CYP27B1 deletion" or "CYP2R1 deletion" and "bone" or "rickets" or "osteomalacia
" or "osteoporosis" or "fracture" or "falls" or "cardiovascular disease" or "heart failure" or "hypertension" or "cardiovascular mortality" or "myocardial infarction" or "stroke." Personal collections of articles on this topic as well as references from selected articles were also used to extend the search.
Herein, we experienced a rare case of insufficiency fracture due to hypophosphatemic osteomalacia
, which was caused by long-term administration of saccharated ferric oxide (SFO).
(TIO) or oncogenic osteomalacia
is an underrecognized paraneoplastic syndrome presenting with hypophosphatemia and typical manifestations of osteomalacia
Vitamin D deficiency can lead to abnormalities in bone metabolism, such as rickets in children or osteomalacia
 More severe degrees of vitamin D deficiency lead to impairment of bone mineralisation and osteomalacia
.  Severe and prolonged vitamin D deficiency causes osteomalacia
This vitamin is essential for bone health with a lack in children leading to rickets, while adults can develop osteomalacia
(1) There was also an unusual case of glomangiopericytoma presenting as a soft-tissue tumor in the buttock area that caused osteomalacia
Low levels of vitamin D can lead to osteoporosis, osteomalacia
, decreased bone mineral density, and risk of acute fracture.