induces secondarily generalized convulsive status epilepticus in rats.
Key words: Orphenadrine
citrate; Paracetamol; caffeine; Reversed-phase HPLC; Acetonitrile; Potassium Hydroxide
Central anticholinergic syndrome from orphenadrine
in a 3 year old.
Characteristic performances and validation for direct potentiometric determination of orphenadrine
Medication classes of users who were secluded during a six-month period at Sterkfontein Hospital Medication Frequency % Nil 11 6.79 Mood stabilisers Na Valproate 28 17.28 Lithium 11 6.79 Carbamazepine 8 4.94 First-generation Haloperidol 18 11.11 antipsychotic Chlorpromazine 12 7.41 Trifluoperazine 2 1.23 Second-generation Clozapine 3 1.85 antipsychotic Risperidone 18 11.11 Olanzapine 1 0.62 Sulpiride 2 1.23 Depot antipsychotic Fluanxol Depot 5 3.09 Clopixol Depot 15 9.26 Modecate 3 1.85 Benzodiazepine Clonazepam 7 4.32 Other Androcur 5 3.09 Orphenadrine
11 6.79 Propranolol 1 0.62 Galantamine 1 0.62
 A Double-blind Trial of Orphenadrine
against placebo  A double blind Trial of Nortryptiline for depression in Chronic Schizophrenia.
Current anticholinergic therapies include benztropine, orphenadrine
Drugs used in Parkinson's Disease Group Drug Dopamine receptor agonists Apomorphine, pramipexole, ropinirole, rotigotine N-Methyl-D-aspartate (NMDA) Amantadine hydrochloride receptor antagonist Levodopa Co/benedopa (levodopa/ benzeraside), co/careldopa (levodopa/carbidopa) Monoamine oxidase B inhibitors Rasagiline, selegiline (MAO-B) hydrochloride Catechol-O-methyltransferase Entacapone, tolcapone (COMT) inhibitors Antimuscarinic drugs Benztropine mesylate, orphenadrine
, procyclidine, trihexyphenidyl Table 2.
M2 EQUITYBITES-September 1, 2011-Sagent Pharmaceuticals Inc receives FDA approval of skeletal muscle relaxant Orphenadrine
Citrate Injection, USP(C)2011 M2 COMMUNICATIONS http://www.m2.com
In addition, GAVIS has launched four niche products, including nifedipine soft gelatin capsules (generic version of Procardia), polyethylene glycol 3350 (generic version of MiraLAX O-T-C), orphenadrine
citrate ER 100 mg tablets (generic version of Norflex) and mesalamine rectal suspension enema (generic version of Rowasa).
One trial (Hoivik and Moe 1983) found more effective pain relief from an 8-day course of Norgesic (ie, combination orphenadrine
35mg and paracetamol 450mg) than placebo (MD -17, 95% CI -32 to -2).
In addition to clozapine, concomitant psychiatric medications were used at discharge in the EG only (with 1 exception) and included valproate (4 cases in EG and 1 in CG), orphenadrine
or benzhexol (3 cases), haloperidol (1 case) and sulpiride (1 case).
citrate, an anticholinergic muscle relaxant, and verapamil, a calcium channel blocker, have both been evaluated for the treatment of NLC in small controlled trials, although neither is FDA approved for this use.
Three drugs have been used in the off-label treatment of NLC: verapamil, orphenadrine
citrate, and quinine sulfate, none of which is FDA approved for this use.