ochronosis


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Words related to ochronosis

an accumulation of dark pigment in cartilage and other connective tissue

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Exogenous Ochronosis and Pigmented Colloid Milium from Hydroquinone Bleaching Creams.
Keywords: Alkaptonuria; lumbar disc hernia; ochronosis.
The histologic features of the surgical specimen were compatible with ochronosis and osteonecrosis [Figure 1]d.
Therefore, the diagnosis of alkaptonuria may be delayed until ochronosis has developed.
Studies have shown that long term hydroquinone use can cause exogenous ochronosis, which is when your skin turns a bluish and black colour Hydroquinone not only inhibits melanin production to help lighten skin, but long term use can actually damage your pigment cells.
Alkaptonuria is a rare metabolic disorder in the phenylalanine and tyrosine catabolic pathway which is characterized by the excessive excretion of homogentisic acid in the urine, ochronosis, and debilitating arthritis of the spine and large joints.
Prolonged use of this ingredient thickens collagen fibers, resulting in ochronosis.
Opinions differ as to why so many African men and women want whiter skin, but whatever the reason, the health implications, which include various types of cancer and ochronosis, a disease which causes hyperpigmentation, which is often irreversible, are causes for concern.
Ochronosis is usually seen in darker skin tones when hydroquinone is used in high concentrations (above 4%) or if a low concentration is used for extended time periods.
Other important consequences of alcaptonuric ochronosis are aortic valve stenosis and urinary tract involvement.
8) Mercury can cause black spots, skin irritation, and in high dosages can cause brain and kidney damage, fetal problems, lung failure, and cancer; hydroquinone is known to cause skin irritation, nephropathy (kidney disease), leukemia, hepato-cellular adenoma (liver cell adenoma), and ochronosis (adverse pigmentation).
As a result, a black pigment, called ochronosis, forms and binds to bone, cartilage and skin.
Ochronosis is a rare metabolic disorder that is characterized by a brownish-black pigmentation of connective tissues.
Finally, one should mention another pigmented lesion that has been reported in the prostate and could theoretically be in the differential diagnosis of a blue nevus--the hereditary pigmentary disorder ochronosis.
Monitor patients for development of exogenous ochronosis, a rare but important adverse effect, Dr.