ochronosis


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Words related to ochronosis

an accumulation of dark pigment in cartilage and other connective tissue

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Loss of approximately 99% of the HGD activity is required to cause symptoms of ochronosis.
Ochronosis is a diagnostic feature of AKU and is seen in nearly 50% of AKU patients (9).
"Exogenous Ochronosis and Pigmented Colloid Milium from Hydroquinone Bleaching Creams." British Journal of Dermatology.
Constant use is associated with exogenous ochronosis.8 Reductions in lesion size, darkness, and severity occurred as early as 4 weeks after treatment and remain significantly reduced throughout the study.9 It is effective in twice daily applications and should be applied to the entire face because bull's-eye areas of discoloration can develop from localized application.10
If children are exposed to this at an early age, they have an increased chance of developing allergies, asthma and eczema." Hydroquinone, usually found in skin- lightening products, certain cleansers and moisturisers, is another harmful drug which can cause ochronosis and hence leave ' disfiguring and irreversible' blue- black lesions on exposed skin.
Given the ankle joint's inherent stability, the most common cause of ankle OA is trauma, (4) mainly ankle fracture and, less commonly, ligamentous injury.5'6 Other rarer causes of ankle arthritis include primary OA, crystalline arthropathy, inflammatory disease, septic arthritis, neuroarthropathy, hemochromatosis, and ochronosis.
Among depigmented population 55% presented stretch marks and 25% for exogenous ochronosis (Table 1).
In addition to the production of dark-colored urine, alkaptonuria is characterized by ochronosis, a bluish-black pigmentation of connective tissue, causing darkening of the skin, the ear, and sclera of the eye.
Accumulation of homogentisic acid and its metabolites in tissues cause ochronosis. The word ochronosis refers to the dark bluish black discoloration of connective tissues including the sclera, cornea, auricular cartilage, heart valves, articular cartilage, tendons, and ligaments.
However, its long-term application has numerous adverse effects, including irritative dermatitis, melanocyte destruction, contact dermatitis, and ochronosis. Matsumoto et al.
Exclusion Criteria: Patients with exogenous ochronosis and males were excluded from the study.
Alkaptonuria (AKU) is an extremely rare autosomal recessive metabolic disorder characterized by a triad of homogentisic aciduria, arthritis, and ochronosis, affecting only 2–5 in a million individuals.[sup][1] The management of AKU is usually symptomatic.
Ochronotic pigment is a black-appearing pigment that accumulates in tissue in association with the autosomal recessive condition of ochronosis. It, however, displays refractile properties under polarized light and has yet to be published within the thyroid gland.
Using them without consulting a doctor can result in hyperpigmentation or ochronosis, a bluish black discolouration of the skin.
Ochronosis is due to a congenital defect in homogentisic acid oxidase leading to homogentisic acid accumulation and its deposition, especially inside joints [9], leading to chondrocyte death and matrix degradation.