When looking at the concentration-dependent effects of calcitriol on VSMC calcification, we observed that 100 and 1000 nM calcitriol supplementation was able to increase the calcification in the presence of high phosphate and only 1000 nM calcitriol supplementation was able to increase the calcification in the presence of normal phosphate
. The first study to reveal detrimental effects of calcitriol supplementation on in vitro VSMC calcification, published in 1998 by Jono et al, showed that calcitriol supplementation (as low as 10 nM) on bovine VSMCs increased calcification in the presence of high phosphate .
His blood tests revealed increased serum creatinine (3.0 mg/dL), normal phosphate
(4.0 mg/dL) and calcium levels (9.7 mg/dL), increased parathyroid hormone (95 pg/mL), and low calcidiol (10.2 ng/mL) and calcitriol (8.1 ng/mL) levels.
One kilogram of this fertilizer has an effect similar to the effect of 500 kg of normal phosphate
and nitrate fertilizer.
His lab findings showed markedly high ionized calcium of 2.9 mmol/l, low intact Parathormone level, normal phosphate
and alkaline phospha- tase, low albumin 22 g/l, uric acid 15.4 u/l, LDH 1090 u/l, serum creatinine1.2 mg/dl.
* As in a normal phosphate
system it will not remove scale or rust