Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial
in postmenopausal women.
This was a multicenter (11 sites), randomized, noninferiority trial
The outcomes of the Norwegian, double-blind, noninferiority trial
, called NOR-SWITCH, indicate similar rates of disease worsening across patients switched to Remsima and those who stayed on Remicade.
Heal et al (1) conducted a prospective, randomized, controlled, noninferiority trial
to compare the incidence of infection after minor skin surgery performed by 6 physicians from a single general practice in Australia using sterile vs non-sterile clean gloves.
In a randomized, double-blind, noninferiority trial
of 1,352 patients who had complicated COPD and an exacerbation, about a fifth of patients had a clinical failure of their antibiotic therapy, no matter which regimen they received, according to results reported at the conference.
Data Source: A phase III noninferiority trial
involving 891 women with invasive node-positive breast cancer treated at 115 medical centers.
A recent noninferiority trial
in 23 patients with infantile hemangiomas compared atenolol 1 mg /kg per day with propranolol 2 mg/kg per day, and followed the patients for 6 months (J.
Investigators compared the two therapies head to head in I-CAN SLEEP (A Comparison of MBSR and CBT for the Treatment of Insomnia in Cancer), a randomized, partially blinded noninferiority trial
among 111 adult patients from a tertiary care center in Calgary, Alta.
The EINSTEIN PE investigators conducted a randomized, unblinded noninferiority trial
to determine whether rivaroxaban was at least as effective as the standard therapy--enoxaparin, followed by a dose-adjusted VKA (warfarin [for US patients] or acenocoumarol) for acute symptomatic PE.
The open-label noninferiority trial
was conducted at 11 sites in nine African, Asian, and Latin American countries.
The investigators performed the noninferiority trial
, known as the REDUCE (Reduction in the Use of Corticosteroids in Exacerbated COPD) study, because no adequately powered, randomized clinical trial has compared directly the outcomes of these two treatment durations.
Outpatient treatment measures up The Outpatient Treatment of Pulmonary Embolism (OTPE) study was a multinational, randomized, noninferiority trial
comparing outpatient vs inpatient treatment of low-risk patients with acute PE.
Although this study was designed as a noninferiority trial
, it was powered to detect superiority.
Data Source: This was a 4-year, randomized, open-label, noninferiority trial
comparing rivaroxaban (2,419 subjects) and standard treatment (2,413 subjects) in 38 countries.
The study by Gurtcheff et al was a randomized controlled noninferiority trial
of 69 women who wanted to use Implanon for postpartum birth control.