In a randomized, open-label, noninferiority trial
that compared the two drugs for treating suspected meningococcal disease, the treatment failure rate at 72 hours was 9% in both groups (247 patients who received ceftriaxone and 256 who received chloramphenicol).
Although the findings must be considered preliminary, as the study was not designed as a noninferiority trial
, the authors concluded that symptom-driven intermittent treatment with inhaled or oral corticosteroids may be possible and could decrease the adverse effects of these agents.
The study, designed as a noninferiority trial
, was sponsored by Gilead Sciences; Gilead markets both tenofovir and emtricitabine, as well as Truvada, the single-pill combination of 300 mg tenofovir and 200 mg emtricitabine.
A total of 1,267 patients were enrolled in this phase III, randomized, doubleblind, noninferiority trial
, including 246 diabetic patients who followed one of the two regimens under study and were considered an intention-to-treat population.
The current noninferiority trial
used few inclusion criteria--just age 18-40 years and first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycle--to prospectively enroll 1,099 women and evenly randomize them to a classic short GnRH-antagonist protocol or a classic long GnRH-agonist protocol.
The researchers directly compared cytisine with nicotine replacement therapy in an open-label, randomized, noninferiority trial
in New Zealand.
Nurses can provide early medication abortion as well as physicians, according to a randomized controlled noninferiority trial
conducted at three Ministry of Health facilities in Mexico City.