Response and Efficacy of Novel Recombinant Tetravalent Dengue DNA Vaccine Comprising Envelope Domain III in Mice.
High rate of subclinical Chikungunya virus infection and association of neutralizing antibody
with protection in a prospective cohort in the Philippines.
The percentage of subjects with a protective neutralizing antibody
titer increased from 69% (137 of 198) on Day 0 before the booster dose to 100% (198 of 198) at Day 28 after the booster dose.
In this study, the vaccine demonstrated strong neutralizing antibody
titers across all three doses tested, exhibiting increasing antibody titers with the escalation of the dose.
We expect that the biological explanations for the development of broadly neutralizing antibody
responses," says Poignard, "are likely to be of special relevance to the design of candidate AIDS vaccines and immunization regimens devised to elicit similar antibodies.
of the California Institute of Technology, the investigators inserted the genes encoding the NIH-discovered broadly HIV neutralizing antibody
VRC01 into a vector, a virus that infects mice but does not cause disease.
These results were obtained even though 91% of the children had circulating dengue or Japanese encephalitis antibodies before vaccination, neutralizing antibodies developed to all 4 DENVs, and neutralizing antibody
titers increased 2-3 fold after 3 doses of vaccine in 80%-90% of vaccinated children.
Rick King is the Vice President of Vaccine Design, overseeing a comprehensive AIDS vaccine discovery program that includes an AIDS Vaccine Design & Development Laboratory in Brooklyn, the Neutralizing Antibody
Center at the Scripps Research Institute in La Jolla, California and a New Translational Research laboratory in Delhi India.
Schief, who is an associate professor of immunology and member of the IAVI Neutralizing Antibody
Center at TSRI.
Finally, VLPs can induce neutralizing antibody
and CTL responses.
When injected into baboons, the two formulations together "exhibited the highest neutralizing antibody
response to date," they report.
These new antibodies, which are more potent than other antibodies described to date while maintaining great breadth, attach to a novel, and potentially more accessible site on HIV to facilitate vaccine design," said Dennis Burton, professor of immunology and microbial science and scientific director of the IAVI Neutralizing Antibody
Center at The Scripps Research Institute in La Jolla, California.
The kind of antibody studied is called a broadly cross-reactive neutralizing antibody
, and details of its generation could provide a blueprint for effective vaccination, the study's researchers said.
Serum samples were obtained from participating pregnant women and their children to measure EV71 neutralizing antibody
titers immediately before delivery for pregnant women; at birth for neonates (cord blood); and at 6, 12, 24, 36, and 48 months of age for infants.
This is the work of the Neutralizing Antibody
Consortium, a global collaboration of researchers organized by IAVI that will take advances from the Theraclone-IAVI partnership forward.