Current study shows that the fades ([TOF.sub.fade] and Fade) caused by 2.2 [micro]-M cisatracurium are progressively worsened ([TOF.sub.fade] = 52.73 [+ or -] 7.2%, n = 4, at T = 15 min and 82.74 [+ or -] 6.35%, n = 4, at T = 30 min; Fade = 100 [+ or -] 0.0%, n = 4, at T = 15 or 30 min), when the parameters (T4/T1 and R = B/A) used to verify levels of fades in neuromuscular transmission
were analyzed 15 min after the instant of administration of neuromuscular relaxant (Figure 2a and d).
An extract of lionfish (Pterosis volitans) spine tissue contains acetylcholine and a toxin that affects neuromuscular transmission
. Toxicon 1989; 27: 1367.
It could also be used as a tool for investigating the effects on neuromuscular transmission
of other drugs and inhalation agents used during anaesthesia.
The use of Botulinum toxin for various cosmetic procedures have been described extensively in literature.7-10,17 Botulinum toxin blocks the neuromuscular transmission
by binding to acceptor sites on motor or sympathetic nerve terminals, thereby inhibiting the release of acetylcholine.
Organophosphate and carbamate pesticides inhibit acetylcholinesterase and lead to accumulation of acetylcholine at sites of neuromuscular transmission
causing weakness of muscles, and paralysis including of respiration.
By days 6-8 post-crush, weak B19-evoked EJPs are detected in Slrt muscle fibers, and spontaneous neuromuscular transmission
is dramatically reduced (Fig.
The relevant locations of concern are (I) impulse propagation along the motor axon into axon branches, (II) neuromuscular transmission
and (III) propagation of action potential along the muscle fibre.
Congenital myasthenic syndromes (CMS) are a group of orphan disorders of neuromuscular transmission
characterized by muscle weakness and fatigability in the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia).
Loss of these receptors from autoimmune destruction leads to a defect in neuromuscular transmission
with muscle weakness and fatigability, the hallmarks of this disorder.
Batrachotoxin blocks neuromuscular transmission
Also discussed by the volume's 18 chapters are neuromuscular junction physiology and pathophysiology; acetylcholine receptor structure; immunopathogenesis of myasthenia gravis; ocular myasthenia; thymona-associated paraneoplastic myasthenia gravis; electrodiagnosis of neuromuscular junction disorders; autoantibody testing in the diagnosis and management of autoimmune disorders of neuromuscular transmission
and related diseases; treatment of myasthenia gravis; neurocritical care of myasthenic crisis; thymectomy for non-thyomatous myasthenia gravis; Lambert-Eaton syndrome; acquired neuromyotonia; congenital myasthenic syndromes; toxic neuromuscular transmission
disorders; and the impact of myasthenia gravis on mood, cognitive function, and quality of life.
Increased body temperatures, pregnancy, emotions, hormonal changes, medications that affect neuromuscular transmission
, illness, and/or infections are associated with disease exacerbation.
Eugenol depresses the neuromuscular transmission
(Ozeki, 1975) and the central nervous system function (Dallmeier and Carlini, 1981).
High doses of [Mg.sup.++] impair neuromuscular transmission
and depress the heart conduction system.
The termination of anaesthesia was permitted as soon as the return of neuromuscular transmission
has arrived at 0.9 TOF ratio either with or without pharmacological reversal.