nephrotoxin


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  • noun

Words related to nephrotoxin

any toxin that affects the kidneys

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References in periodicals archive ?
Therefore, apart from the usual advice of smoking cessation, alcohol moderation, maintaining ideal body weight, avoiding nephrotoxins, maintaining blood pressure and blood sugar at target levels, and reducing proteinuria using well-known prescribed methods, we advise the use of all other possible but safe modalities to slow functional deterioration.
(7.) Berndt WO: Ochratoxin-citrinin as nephrotoxins. In Llewellyn GC & Rear PC (Edn.), Biodeterioration Research 3.
Finally, the end product of the polyol pathway, fructose, has also recently emerged as a potential nephrotoxin. In a diabetic murine model, endogenous production of fructose through the polyol pathway led to increased proteinuria, reduced GFR, and increased glomerular and proximal tubular injury when compared to mice with lower levels of endogenous fructose.
However, in the near future physicians will likely use a panel of biomarkers (traditional and novel) to diagnose AKI, with different combinations excelling in certain clinical settings (sepsis, cardiac surgery, nephrotoxin) as well as at different clinical time points (in the emergency room, time of ICU admission, onset of clinical AKI).
Striker, "Nephrotoxin exposure in utero reduces glomerular number in sclerosis-prone but not in sclerosis-resistantmice," Kidney International, vol.
Amphotericin B is a known nephrotoxin; increases in serum urea and creatinine have been reported to occur in over 80% of patients treated with this drug [17,18].
Editorial Note: DEG, a known nephrotoxin and hepatotoxin, is used in industrial solvents and antifreeze.
Multiple factors, including renal hypoperfusion, hypovolemia, ischemia-reperfusion, neurohumoral including renin-angiotensin system activation, and nephrotoxin exposure especially anti-rejection medications, are known to contribute to this renal dysfunction in organ transplantation setting [4, 10].
The ATN mechanisms were sepsis in 24 cases, hypoperfusion in 15 and nephrotoxin in 6.
AKI related to nephrotoxins, alternative (traditional) medicines, infectious agents, and hospitalizations and related procedures are more pronounced in low-income and lower-middle-income countries and contribute to increased risk of mortality and CKD in those settings (35).
[3] The epidemiology of AKI in developing countries is unique in that certain causes, such as the infections, obstetric causes, and nephrotoxins, which are largely obsolete in developed countries remain important causes in developing countries.
Both bilirubin and bile salts are potential nephrotoxins in animal models, but their precise role in pathogenesis of jaundice related nephropathy is unknown.
Risk factors for renal disease in HIV patients include CD4 count <200 cells/microliter, HIV viremia particularly RNA levels > 400 copies/ml, [5] African-American race, family history of kidney disease, use of nephrotoxins, comorbidities like diabetes, hypertension, hepatitis c co infection.
There were no statistically significant differences between the four treatment groups in terms of AKI incidence, vancomycin trough, use of other nephrotoxins, or duration of therapy (p>0.05).