Amiloride restores renal medulary osmolytes in lithium-induced nephrogenic diabetes insipidus
. Am J Physiol Renal Physiol.
Hereditary nephrogenic diabetes insipidus
in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2.
Primary polydipsia Central diabetes insipidus Nephrogenic diabetes insipidus
Obstructive uropathy Renal failure Conn's syndrome Addisonian crisis Diabetes mellitus Hypokalemia Hypercalciuria Hypercalcemia Bartter syndrome Fanconi syndrome Sickle cell anemia Anorexia nervosa Table 2: Interpretation of serum and urine osmolality in the differential diagnosis of polyuria and polydipsia after the water deprivation test.
Novel treatment for lithium-induced nephrogenic diabetes insipidus
rat model using the Sendai-virus vector carrying aquaporin 2 gene.
Nephrogenic diabetes insipidus
occurs more commonly than CDI, most frequently from lithium toxicity accounting for 15 to 40% of causes.
ABBREVIATIONS: ADH = anti-diuretic hormone; AQP = aquaporin; AMP = adenosine monophosphate; cAMP = cyclic AMP; CD = collecting duct; cDNA = complementary DNA; CHF = congestive heart failure; DCT = distal convoluted tube; NDI = nephrogenic diabetes insipidus
; PCT = proximal convoluted tubule; RBC = red blood cells; RT PCR = reverse transcription - polymerase chain reaction.
Table 2 Aquaporin Expression Disorders Water Retaining Disorders Water Losing Disorders (Underexpression of (Overexpression of aquaporins) aquaporins) Hereditary nephrogenic diabetes insipidus
SIADH Acquired nephrogenic diabetes insipidus
Vasopressin escape Lithium Congestive heart failure Primary polydipsia Cirrhosis Hypokalemia Pregnancy Hypercalcemia Glucocorticoid deficiency Urinary tract obstruction Acute and chronic renal failure Nephrotic syndrome Hypothyroidism Low protein diet References
Molecular and cellular defects in nephrogenic diabetes insipidus
. Curr Opin Nebrol Hypertens.
Plasma AVP of five patients with nephrogenic diabetes insipidus
was substantially increased (7.7 [+ or -] 4.5 ng/L).
Igarashi, "Salt-losing nephrogenic diabetes insipidus
caused by fetal exposure to angiotensin receptor blocker," Pediatric Nephrology, vol.
Diagnosing lithium-induced nephrogenic diabetes insipidus
(NDI) begins with a history of the patient's symptoms and ordering lab tests.
We seek to explain this delayed onset by a discussion of the molecular and genetic changes underlying the pathogenesis of lithium-induced nephrogenic diabetes insipidus
ABBREVIATIONS: ADH = anti-diuretic hormone; AQP = aquaporin; cAMP= cyclic adenosine monophosphate; CDI = central diabetes insipidus; CHF = congestive heart failure; MIP = major intrinsic protein; NDI = nephrogenic diabetes insipidus
; PCT = proximal convoluted tubule; RT PCR = reverse transcription - polymerase chain reaction; SS = Sjogren's syndrome; SIADH = syndrome of inappropriate ADH secretion.
Nephrogenic diabetes insipidus
(NDI) is a rare disease that is characterized by resistance of the distal renal tubule and collecting ducts to arginine vasopressin [1,2].
Furthermore, as in the present case, type 1 Bartter syndrome may be characterized by severe hypernatremia and urinary concentration defect, suggesting an erroneous diagnosis of nephrogenic diabetes insipidus
. In these atypical cases, molecular analysis is necessary to define the diagnosis.